Abstract
Objective
To outline serum estradiol levels in perimenopausal women with stress, mixed or urge
incontinence. We believe the majority of urgency symptoms in perimenopausal women
to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck.
If this is the case, there would be no difference in estradiol levels between the
groups.
Study design
Setting: University hospital. In the observational Women's Health in the Lund Area
study, a subset of 400/2221 women reporting urinary incontinence completed a detailed
questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone
levels measured. Statistical analyses were made by Chi-square test, nonparametrical
tests, ANOVA, multi- and univariate logistic regression analysis.
Results
Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence
by 43 women; in 369, serumestradiol values were available. Serum estradiol did not
differ significantly between stress incontinent (median 49.5 pmo/l, range 2.63–875.4), urge incontinent (median 31.6 pmol/l, range 2.63–460.7) or mixed incontinent women (median 35.5 pmol/l, range 2.63–787.9, p = 0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking,
hysterectomy and BMI also failed to show any difference in estradiol levels between
the groups (p = 0.41–0.58).
Conclusion
No significant differences in serum estradiol levels between stress, mixed or urge
incontinent perimenopausal women could be demonstrated.
Keywords
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Article info
Publication history
Published online: July 08, 2011
Accepted:
June 9,
2011
Received in revised form:
June 3,
2011
Received:
December 19,
2010
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
