To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups.
Setting: University hospital. In the observational Women's Health in the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured. Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi- and univariate logistic regression analysis.
Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women; in 369, serumestradiol values were available. Serum estradiol did not differ significantly between stress incontinent (median 49.5 pmo/l, range 2.63–875.4), urge incontinent (median 31.6 pmol/l, range 2.63–460.7) or mixed incontinent women (median 35.5 pmol/l, range 2.63–787.9, p = 0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p = 0.41–0.58).
No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated.
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- Oestrogens and lower urinary tract function.Maturitas. 2000; 36: 83-92
- Age dependent response to exogenous estrogen on micturition, contractility and cholinergic receptors of the rat bladder.Life Sci. 1999; 64: 279-289
- Urodynamic studies in the normal menstrual cycle: the relationship between hormonal changes during the menstrual cycle and the urethral pressure profile.Am J Obstet Gynecol. 1981; 141: 384-392
- The use of estrogen in the treatment of dysuria and incontinence in postmenopausal women.Am J Obstet Gynecol. 1941; 14: 23-31
- Oestrogens for urinary incontinence in women.Cochrane Database Syst Rev. 2003; 2: CD001405
- Estrogen therapy in the management of urinary incontinence in postmenopausal women: a meta-analysis. First report of the Hormones and Urogenital Therapy Committee.Obstet Gynecol. 1994; 83: 12-18
- Efficacy of estrogen supplementation in the treatment of urinary incontinence. The Continence Program for Women Research Group.Obstet Gynecol. 1996; 88: 745-749
- The effect of oestrogen supplementation on post-menopausal urinary stress incontinence: a double-blind placebo-controlled trial.BRJOG. 1999; 106: 711-718
- Effects of estrogen with and without progestin on urinary incontinence.JAMA. 2005; 293: 935-948
- Postmenopausal hormone therapy and risk of developing urinary incontinence.Obstet Gynecol. 2004; 103: 254-260
- Factors associated with worsening and improving urinary incontinence across the menopausal transition.Obstet Gynecol. 2008; 111: 667-677
- Oestrogen therapy for urinary incontinence in post-menopausal women.Cochrane Database Syst Rev. 2009; (Art. No.: CD001405. doi:10.1002/14651858.CD001405.pub2)
- The relation between urinary incontinence and steroid hormone levels in perimenopausal women. A report from the Women's Health in the Lund Area (WHILA) study.Acta Obstet Gynecol Scand. 2009; 88: 927-932
- The Women's Health In the Lund Area (WHILA) study – an overview.Maturitas. 2010; 65: 37-45
- The standardisation of terminology of lower urinary tract function. The International Continence Society Committee on Standardisation of Terminology.Scand J Urol Nephrol Suppl. 1988; 114: 5-19
- A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT Study.J Clin Epidem. 2000; 53: 1150-1157
- Urinary incontinence in elderly women: findings from the Health, Aging and Body composition study.Obstet Gynecol. 2004; 104: 301-307
- Postmenopausal hormones and incontinence: the Heart and Estrogen/Progestin Replacement Study.Obstet Gynecol. 2001; 97: 116-120
- Epidemiology and natural history of urinary incontinence.in: Abrams P. Khoury S. Wein A. Incontinence. Health Publication Ltd., Monaco1999: 197-226
- Epidemiology and natural history of urinary incontinence in women.Urology. 2003; 62: 16-23
- Medical correlates of urinary incontinence in the elderly.Urology. 1990; 36: 129-138
- Association of change in estradiol to lower urinary tract symptoms during the menopausal transition.Obstet Gynecol. 2008; 112: 1045
- The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence.BJOG. 2002; 109: 339-344
- Effects of estrogen and progestin replacement on the urogenital tract of the ovariectomized cynomolgus monkey.Neurourol Urodyn. 1996; 15: 215-221
- Does urinary incontinence occurrence depend on the menstrual cycle phase?.Acta Obstet Gynecol Scand. 2001; 81: 347-350
- Menstrual cycle, female hormone use and urinary incontinence in premenopausal women.Int Urogynecol J. 2003; 14: 56-61
- Menstrual phase-dependent gene expression differences in periurethral vaginal tissue from women with stress incontinence.Am J Obstet Gynecol. 2003; 189: 89-97
Published online: July 08, 2011
Accepted: June 9, 2011
Received in revised form: June 3, 2011
Received: December 19, 2010
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.