Abstract
Objective
To determine the effect of a sudden decrease in estrogen levels via bilateral oophorectomy
on serum turnover markers and to examine their correlation with bone mineral density
(BMD).
Study design
This study included 51 women who had regular menses preoperatively and underwent bilateral
oophorectomy for benign reasons. These women did not have any systemic disease or
drug use that would influence bone metabolism. For each woman, spine and femur BMD
were measured preoperatively and sixth months after surgery. Serum C-terminal telopeptide
(CTX) and bone alkaline phosphatase (BAP) were measured preoperatively and at the
first and sixth months after surgery. Correlations between bone turnover markers and
BMD were pre- and post-operatively analyzed.
Results
The mean serum CTX and BAP concentrations at the first and sixth postoperative months
were significantly higher compared to the preoperative measurements (p = 0.001). Spine BMD values at the sixth postoperative month was significantly lower
compared to preoperative period (p = 0.0001). There was a significant negative correlation between spine BMD values and
BAP levels both in the preoperative period and at the sixth postoperative month (r = −0.407, p = 0.001), whereas a significant positive correlation between serum CTX and BAP was noted
at this time periods (r = 0.615, p < 0.001).
Conclusions
The results of this study showed that serum BAP and CTX levels rapidly increase in
women after bilateral oophorectomy. Therefore, these markers (especially BAP) could
be useful in the evaluation of osteoporosis risk in the early period of surgical menopause.
Keywords
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Article info
Publication history
Published online: June 27, 2011
Accepted:
June 9,
2011
Received in revised form:
May 5,
2011
Received:
October 20,
2010
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
