Abstract
Objective
To examine the use of squamous cell carcinoma antigen (SCCA) as a biomarker of chemotherapy
response in patients who underwent chemotherapy for metastatic cervical carcinoma.
Study design
The study population consisted of patients who underwent first-line chemotherapy for
metastatic cervical carcinoma between 1999 and 2009. SCCA levels were serially measured
before, during and after chemotherapy. Radiographic responses were evaluated according
to the criteria of the World Health Organization. A logistic model was used to determine
the best prediction model, and internal and external validation of the prediction
model were performed to compare the areas under the receiver operating characteristic
curves (AUCs).
Results
In total, 55 patients were included in the analysis. Data for 32 patients enrolled
in various clinical trials were used to develop the prediction model. Patients who
achieved a radiographic response showed a significant decline in SCCA levels between
the second and third cycles of chemotherapy, whereas patients who did not achieve
a radiographic response showed constant SCCA levels over the same period. The prediction
model was developed on the basis of changes in the SCCA level between the second and
third cycles of chemotherapy (AUC = 0.832) and the baseline SCCA level. The AUC after external validation, calculated
using the data of the clinical practice population (n = 22), was 0.871.
Conclusions
A response to chemotherapy was possible for patients in whom SCCA levels declined
between the second and third cycles of chemotherapy.
Keywords
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Article info
Publication history
Published online: July 21, 2011
Accepted:
July 5,
2011
Received in revised form:
October 28,
2010
Received:
May 30,
2010
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
