Abstract
Objective
To study the association of vascular endothelial growth factor (VEGF) polymorphisms
(−2578C>A, −1154G>A, −634G>C, and 936C>T) with premature ovarian failure (POF) in
Korean patients.
Study design
Prospective case–control study. One hundred and thirty five patients with POF and
confirmed serum follicle-stimulating hormone levels of >40 IU/L before the age of 40 years and 120 healthy controls with at least one live birth,
regular menstrual cycles, and karyotype 46, XX.
Results
POF patients exhibited significantly different frequencies of the VEGF −1154GA genotype
(odds ratio [OR], 2.002; 95% confidence interval [CI], 1.116–3.592; P = 0.019), and −2578CA+AA/−1154GA+AA combination genotype (OR, 1.805; 95% CI, 1.013–3.217;
P = 0.044) compared to the control group. The frequency of the −2578A/−1154A haplotype
(OR, 1.647; 95% CI, 1.017–2.677; P = 0.041) was significantly higher in the POF group than in the control group.
Conclusion
The VEGF −1154G>A mutation, −2578CA+AA/−1154GA+AA combination genotype, and −2578A/−1154A
haplotype are significantly associated with POF in Korean women.
Keywords
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Article info
Publication history
Published online: July 29, 2011
Accepted:
July 11,
2011
Received in revised form:
May 20,
2011
Received:
December 30,
2010
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
