Abstract
Objective
The negative effects of cigarette smoking on human reproduction and on birth weight
are well documented. On the other hand ABO system, encoding for glycosyltransferases,
contributes to biosynthesis of antigens and oligosaccharide structures involved in
blastocyst adhesion and intrauterine selection. In this paper we have searched for
possible interaction between ABO system and smoking concerning their effects on maternal
age at child bearing and on birth weight.
Study design
We have studied 395 consecutive healthy puerperae from the White Caucasian population
of Rome. ABO blood group was determined by standard laboratory methods. Three-way
contingency table analysis was performed according to Sokal and Rohlf and Chi square
test of independence by SPSS programs.
Results
The proportion of smokers is higher in A phenotype than in other ABO types among young
puerperae (≤24 years) while it is lower in A phenotype than in other types among older
women. The negative effects of smoke on birth weight is much more evident in women
with A blood group than in women carrying other ABO phenotypes. The interaction between
smoking and ABO blood groups concerning their effects on birth weight is influenced
by gender of newborn and by maternal age.
Conclusion
ABO blood groups and smoking could have a joint influence on maternal age at child
bearing and on birth weight.
Keywords
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Article info
Publication history
Published online: July 29, 2011
Accepted:
July 11,
2011
Received in revised form:
July 4,
2011
Received:
April 26,
2011
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
