Abstract
The aim of this study was to perform a meta-analysis of the potential effects of oocyte
morphological abnormalities on ICSI outcomes. Relevant original papers reporting on
the relation between oocyte morphology and ICSI outcomes were identified by searching
MEDLINE, EMBASE and the Cochrane Library. The main outcome measures were fertilisation
rate and embryo quality. A meta-analysis was performed and Mantel–Haenszel pooled
odd ratios (ORs) with 95% confidence intervals (CIs) were calculated to express the
relation between the oocyte morphology and the ICSI outcomes. A total of 14 studies
reporting 3688 ICSI cycles were included. Our meta-analysis demonstrates that the
probability of an oocyte becoming fertilised is significantly reduced by the presence
of large IPB (OR: 0.29, CI: 0.09–0.90), large PVS (OR: 0.86, CI: 0.74–0.99), refractile
bodies (OR: 0.66, CI: 0.51–0.84) or vacuoles (OR: 0.59, CI: 0.42–0.83). No other investigated
morphological abnormalities demonstrated significant relationships with ICSI outcomes.
Our data demonstrate that the presence of large IPB, large PVS, refractile bodies
or vacuoles is associated with decreased oocyte fertilisation. Our findings might
be of importance for selecting embryos for replacement because the effects of oocyte
abnormalities on implantation and pregnancy rates remain unclear.
Keywords
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Article info
Publication history
Published online: August 01, 2011
Accepted:
July 14,
2011
Received in revised form:
July 12,
2011
Received:
April 18,
2011
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
