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Review| Volume 159, ISSUE 2, P261-266, December 2011

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Acute pancreatitis in pregnancy: an overview

  • Efstathios P. Papadakis
    Affiliations
    3rd Department of Obstetrics and Gynecology, Hippokration General Hospital, Aristotle University Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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  • Maria Sarigianni
    Affiliations
    Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London NW3 2QG, UK
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  • Dimitri P. Mikhailidis
    Affiliations
    Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London NW3 2QG, UK
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  • Apostolos Mamopoulos
    Correspondence
    Corresponding author at: 133, Tsimiski Str., 54621 Thessaloniki, Greece. Tel.: +30 6937272617; fax: +30 2310992950.
    Affiliations
    3rd Department of Obstetrics and Gynecology, Hippokration General Hospital, Aristotle University Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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  • Vasilios Karagiannis
    Affiliations
    3rd Department of Obstetrics and Gynecology, Hippokration General Hospital, Aristotle University Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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      Abstract

      Acute pancreatitis is rare in pregnancy but it is associated with increased incidence of maternal and fetal mortality. It should be considered in the differential diagnosis of upper quadrant abdominal pain with or without nausea and vomiting. The commonest identified causes of acute pancreatitis in pregnancy are gallstones, alcohol and hypertriglyceridemia. The main laboratory finding is increased amylase activity. Appropriate investigations include ultrasound of the right upper quadrant and measurement of serum triglycerides and ionized calcium. Management of gallstone pancreatitis is controversial, although laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) are often used and may be associated with lower complication rates. In hypertriglyceridemia-induced acute pancreatitis ω-3 fatty acids and even therapeutic plasma exchange can be used. We also discuss preventive measures.

      Keywords

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