Abstract
Objective
Fertility declines with age. A study of the outcomes of in vitro maturation (IVM)
in women of different ages has not been reported to date. The aim of our study was
to evaluate the impact of age on treatment response and on pregnancy rates after IVM
treatment.
Study design
We reviewed the data of all IVM cycles and recorded the total number of oocytes, total
metaphase II (MII) oocytes, the number and quality of embryos as well as pregnancy
rates. The main outcome measures were number and maturity of retrieved oocytes and
pregnancy rates.
Results
Compared to cycles in women ≤25 years, the number of oocytes and total MII oocytes
were significantly lower in women over 40 years. The number of good quality embryos
in women ≤25 years (3.6 ± 1.7) was higher than in women aged 40 years (0.8 ± 1.2, P < 0.0001). The ongoing pregnancy rates in women aged 20–25 years were 36.8%, 26–35 years
were 30.0% and in those 36–39 years were 31.9%. No clinical pregnancy was observed
in women over the age of 40.
Conclusion
Women over 40 years are poor candidates for IVM treatment.
Keywords
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References
- Outcome of assisted reproductive technology in women over the age of 41.Fertil Steril. 2000; 74: 471-475
- Cumulative conception and livebirth rates after in-vitro fertilisation.Lancet. 1992; 339: 1390-1394
- Female age predicts embryonic implantation after ICSI: a case-controlled study.Hum Reprod. 1996; 11: 1324-1327
- The age-related decline in female fecundity: a quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization.Fertil Steril. 1996; 65: 783-790
- In-vitro fertilization and embryo transfer in women aged 40 years and over.Hum Reprod Update. 1996; 2: 459-468
- Age-related changes of the population of human ovarian follicles: increase in the disappearance rate of non-growing and early-growing follicles in aging women.Biol Reprod. 1994; 50: 653-663
- A model conforming the decline in follicle numbers to the age of menopause in women.Hum Reprod. 1996; 11: 1484-1486
- embryological aspects of hCG-primed in vitro maturation cycles for patients with polycystic ovaries.Hum Reprod Update. 2010; 16: 675-689
- Outcome of in vitro fertilization in women 45 years and older who use autologous oocytes.Fertil Steril. 2007; 87: 74-76
- Factors that affect outcome of in-vitro fertilisation treatment.Lancet. 1996; 348: 1402-1406
- Cumulative pregnancy rate following in-vitro fertilization: the significance of age and infertility aetiology.Hum Reprod. 1996; 11: 425-428
- Factors predicting IVF treatment outcome: a multivariate analysis of 5310 cycles.Reprod Biomed Online. 2005; 10: 645-649
- What should be the first-line treatment for unexplained infertility in women over 40 years of age – ovulation induction and IUI, or IVF?.Reprod Biomed Online. 2009; 19: 4334
- Cellular and molecular aspects of ovarian follicle ageing.Hum Reprod Update. 2008; 14: 131-142
Article info
Publication history
Published online: September 19, 2011
Accepted:
September 5,
2011
Received in revised form:
July 10,
2011
Received:
May 13,
2011
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
