Maternal caffeine intake and its effect on pregnancy outcomes

  • Mirosław Jarosz
    Corresponding author. Tel.: +48 22 550 96 77; fax: +48 22 842 11 03.
    Department of Nutrition and Dietetics with Clinic of Metabolic Diseases and Gastroenterology, National Food and Nutrition Institute, Powsińska St. 61/63, 02-903 Warsaw, Poland
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  • Regina Wierzejska
    Department of Nutrition and Dietetics with Clinic of Metabolic Diseases and Gastroenterology, National Food and Nutrition Institute, Powsińska St. 61/63, 02-903 Warsaw, Poland
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  • Magdalena Siuba
    Department of Nutrition and Dietetics with Clinic of Metabolic Diseases and Gastroenterology, National Food and Nutrition Institute, Powsińska St. 61/63, 02-903 Warsaw, Poland
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Published:November 28, 2011DOI:



      Estimation of the maternal caffeine intake during pregnancy and its influence on pregnancy duration, birthweight and Apgar score of the newborn.

      Study design

      The research was conducted on pregnant women who gave birth at the Clinic of Obstetrics, Gynaecology and Oncology, 2nd Faculty of Medicine, Medical University of Warsaw. It covered unifetal pregnancies without diseases (N = 509). Research data were collected by direct questionnaire supplemented with data from patients’ records. Statistical analysis employed a multivariate logistic regression model and a non-parametric Spearman's rank correlation coefficient.


      98.4% of pregnant women consume no more than 300 mg of caffeine per day. Pregnant women who smoke and older women consume more caffeine than non-smokers and younger women [β 1.95 (95% CI: 1.02–2.88)] and [β 0.68 (95% CI: 0.05–1.3)] respectively. There is no association between maternal caffeine intake during pregnancy and the risk of premature birth, the birthweight or the Apgar score of newborns.


      Caffeine intake of no more than 300 mg per day during pregnancy does not affect pregnancy duration and the condition of the newborn.


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        • Care Study Group
        Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study.
        BMJ. 2010; 340: c2331
        • Kuczkowski K.M.
        Caffeine in pregnancy.
        Arch Gynecol Obstet. 2009; 280: 695-698
        • Grosso L.M.
        • Triche E.W.
        • Belanger K.
        • Benowitz N.L.
        • Holford T.R.
        • Bracken M.B.
        Caffeine metabolites in umbilical cord blood: cytochrome P-450 1A2 activity and intrauterine growth restriction.
        Am J Epidemiol. 2006; 163: 1035-1041
        • Bakker R.
        • Steegers E.A.P.
        • Obradov A.
        • Raat H.
        • Hofman A.
        • Jaddoe V.W.V.
        al caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study.
        Mater Am J Clin Nutr. 2010; 91: 1691-1698
        • Grosso L.M.
        • Bracken M.B.
        Caffeine metabolism, genetics and perinatal outcomes: a review of exposure assessment considerations during pregnancy.
        Ann Epidemiol. 2005; 15: 460-466
        • Maslowa E.
        • Bhattacharya S.
        • Lin S.W.
        • Michels K.B.
        Caffeine consumption during pregnancy and risk of preterm birth: a meta-analysis.
        Am J Clin Nutr. 2010; 92: 1120-1130
        • Nawrot P.
        • Jordan S.
        • Eastwood J.
        • Rotstein J.
        • Hugenholtz A.
        • Feeley M.
        Effects of caffeine on human health.
        Food Addit Contam. 2003; 20: 1-3
        • Eskenazi B.
        Caffeine-filtering the facts.
        N Engl J Med. 1999; 341: 1688-1689
        • Higdon J.V.
        • Frei B.
        Coffee and health: a review of recent human research.
        Crit Rev Food Sci Nutr. 2006; 46: 101-123
      1. Food Standards Agency New caffeine advice for pregnant women. 3 November, 2008

        • Weng X.
        • Odouli R.
        • Li D.K.
        Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study.
        Am J Obstet Gynecol. 2008; 198: 279.e1-279.e8
        • Bracken M.B.
        • Triche E.W.
        • Belanger K.
        • Hellenbrand K.
        • Leaderer B.P.
        Association of maternal caffeine consumption with decrements in fetal growth.
        Am J Epidemiol. 2003; 157: 456-466
        • Mills J.L.
        • Holmes L.B.
        • Aarons J.H.
        • Simpson J.L.
        • Brown Z.A.
        Moderate caffeine use and the risk of spontaneous abortion and intrauterine growth retardation.
        JAMA. 1993; 269: 593-597
        • Clausson B.
        • Granath F.
        • Ekbom A.
        • et al.
        Effect of caffeine exposure during pregnancy on birth weight and gestational age.
        Am J Epidemiol. 2002; 155: 429-436
        • Białas M.
        • Łuczak H.
        • Przygoński K.
        Zawartość kofeiny w wybranych napojach kawowych w proszku.
        Bromat Chem Toksykol. 2009; 3: 426-430
        • Mandel H.G.
        Update on caffeine consumption, disposition and action.
        Food Chem Toxicol. 2002; 40: 1231-1234
        • Camargo M.C.
        • Toledo M.C.
        • Farah H.G.
        Caffene daily intake from dietary sources in Brazil.
        Food Addit Contam. 1999; 16: 79-87
        • Beck S.
        • Wojdyla D.
        • Say L.
        • et al.
        The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity.
        Bull World Health Organ. 2010; 88: 1-80
        • Casey B.
        • McIntire D.
        • Leveno K.
        The continuing value of the Apgar score for the assessment of newborn infants.
        N Engl J Med. 2001; 344: 467-471
        • ÓDonnell C.P.
        • Kamlin C.O.
        • Davis P.G.
        • Carlin J.B.
        • Morley C.J.
        Interobserver variability of the 5-minute Apgar score.
        J Pediatr. 2006; 149: 486-489
      2. Stata Statistical Software Release 10, College Station, TX, Stata Corporation.

        • Knight C.A.
        • Knight I.
        • Mitchell D.C.
        • Zepp J.E.
        Beverage caffeine intake in US consumers and subpopulations of interest: estimates from the Share of Intake Panel survey.
        Food Chem Toxicol. 2004; 42: 1923-1930
        • Frary C.D.
        • Johnson R.K.
        • Wang M.Q.
        Food sources and intakes of caffeine in the diets of persons in the United States.
        J Am Diet Assoc. 2005; 105: 110-113
        • Elind E.
        • Bye A.
        • Brantseter A.
        • et al.
        Influnce of caffeine intake during pregnancy on birth weight: a study based on data from a sub-cohort in the Norwegian Mother and Child Cohort Study (MoBa) at the Norwegian Institute of public Health.
        Ann Nutr Metab. 2007; 51: 1-422
        • Grosso L.M.
        • Triche E.W.
        • Benowitz N.L.
        • Bracken M.B.
        Prenatal caffeine assessment: fetal and maternal biomarkers or self-reported intake?.
        Ann Epidemiol. 2008; 18: 172-178
        • Martin T.R.
        • Bracken M.B.
        The association between low birthweight and caffeine consumption during pregnancy.
        Am J Epidemiol. 1987; 126: 813-821
        • Bech B.H.
        • Obel C.
        • Henriksen T.B.
        • Olsen J.
        Effect of reducing caffeine intake on birth weight and length of gestation; randomised controlled trial.
        BMJ. 2007; 334: 409
        • Fortier I.
        • Marcoux S.
        • Beaulac-Baillargeon L.
        Relaton of caffeine intake during pregnancy to intrauterine growth retardation and preterm birth.
        Am J Epidemiol. 1993; 137: 931-940
        • Bicalho G.G.
        • Filho B.A.
        Birthweight and caffeine consumption.
        Rev Saude Publ. 2002; 36: 180-187
        • Linn S.
        • Schoenbaum S.
        • Monson R.
        • Rosner B.
        • Stubblefield P.
        • Ryan K.
        No association between coffee consumption and adverse outcomes of pregnancy.
        N Engl J Med. 1982; 306: 141-145
        • Santos I.
        • Victora C.
        • Huttly S.
        Caffeine intake and low birth weight: a population-based case–control study.
        Am J Epidemiol. 1998; 147: 620-626
        • Suteerapataranon S.
        • Butsoongnern J.
        • Punturat P.
        Caffeine in Chiang Rai tea infusions: effects of tea variety, type, leaf form, and infusion conditions.
        Food Chem. 2009; 114: 1335-1338
        • Fredholm B.B.
        • Bätting K.
        • Holmén J.
        • Nehlig A.
        • Zvartau E.E.
        Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.
        Pharmacol Rev. 1999; 51: 83-126
        • Jarosz M.
        • Wierzejska R.
        • Mojska H.
        • Świderska K.
        • Siuba M
        Caffeine content in food products.
        Bromat Chem Toksykol. 2009; 3: 776-781