Abstract
Objective
To study the recurrence rate and predictive factors for recurrence after surgical
excision of ovarian mature cystic teratomas (MCT).
Study design
Retrospective study of 382 patients who underwent surgical excision of MCT and whose
post-surgical follow-up data were available over six months. Patients who underwent
concomitant oophorectomy or had a history of oophorectomy were excluded. Medical records
were reviewed for evidence of recurrence. The Cox-hazard model was used for the estimation
of predictive factors for recurrence. Categorical data were compared using the Chi-square
and Fisher's exact tests.
Results
There were 16 recurrences within a mean follow-up period of 43.0 months, with a recurrence
rate of 4.2%. Young age (<30 years old, Y) (hazard ratio (HR) 2.98; 95% confidence
interval (CI) 1.04–8.62, P = 0.043), large cyst (≥8 cm in diameter, L) (HR 2.75; 95% CI 1.03–7.37, P = 0.044), and bilaterality (B) (HR 2.88; 95% CI 1.07–7.76, P = 0.036) were shown to be significant predictive factors. When a patient had all these
three factors, the recurrence rate was 21.0%, otherwise 3.4% (P < 0.01). Patients with Y + L, Y + B, and B + L also showed significantly higher recurrence rate (21.4%, 15.9%, and 11.4%, respectively).
Conclusion
The long-term recurrence rate after surgical excision of MCT in this study is 4.2%.
A patient with young age (<30 years old) or large cyst (≥8 cm in diameter) or bilateral cysts is at high risk of recurrence, which is even higher
when a patient has more than one of these factors.
Keywords
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References
- Benign cystic teratomas of the ovary; a clinico-statistical study of 1007 cases with a review of the literature.Am J Obstet Gynecol. 1955; 70: 368-382
- Germ cell tumors of the ovary arising after dermoid cyst resection: a long-term follow-up study.Obstet Gynecol. 1994; 83: 605-608
- Benign cystic teratoma of the ovary: a 6-year review.Can J Surg. 1985; 28: 444-446
- Treatment of ovarian dermoid cysts. Place and modalities of operative laparoscopy.Surg Endosc. 1994; 8: 1092-1095
- Short-term morbidity and long-term recurrence rate of ovarian dermoid cysts treated by laparoscopy versus laparotomy.J Obstet Gynaecol Can. 2006; 28: 789-793
- Laparoscopic conservative removal of ovarian dermoid cysts.J Am Assoc Gynecol Laparosc. 1996; 3: 409-411
- Surgical treatment of ovarian dermoid cysts.Eur J Obstet Gynecol Reprod Biol. 1998; 81: 47-50
- The management of mature cystic teratomas in children and adolescents: a retrospective analysis.Hum Reprod. 2000; 15: 2669-2672
- Immunohistochemical characteristics of mature ovarian cystic teratomas in patients with postoperative recurrence.Int J Gynecol Pathol. 2006; 25: 95-100
Article info
Publication history
Published online: September 16, 2013
Accepted:
September 2,
2013
Received in revised form:
July 26,
2013
Received:
May 4,
2013
Identification
Copyright
© 2013 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
