Abstract
Objective
HBV vertical transmission is the main reason for chronic HBV infection, but there
is no clear conclusion about the effect of HBV infection on pregnancy outcome. This
study aimed to investigate the effect of HBV-infected embryos on pregnancy outcome.
Study design
75 couples who received ART treatment were followed up. Among them were 25 couples
(group A) with at least the husband or wife infected with HBV, and 50 couples (group
B) with negative serum HBV markers of both husband and wife. The clinical pregnancy
rate, early abortion rate, neonatal malformation rate, neonatal HBV infection rate,
and HBV infection rate of the six-month-old infant were compared between these two
groups, and Fisher's exact test was applied. HBV mRNA in abandoned embryos of the
patients was detected by single-cell RT-PCR.
Results
Both the early abortion rate and the abortion rate with the mother infected HBV in
group A were significantly higher than in group B (P = 0.043, P = 0.030 respectively). The clinical pregnancy rates of groups A and B were 36% and 44%
respectively (P = 0.248 > 0.05). The neonatal malformation rate, neonatal HBV infection rate, and HBV infection
rate of six-month-old infants in group A and group B were all 0. Specific HBV mRNA
fragments were detected in 6 cases of 62 cleavage embryos in group A, giving a positive
rate of 9.7%. The positive rates with mother infected and father infected with HBV
were 13.2% (5/38) and 5.6% (1/18) respectively.
Conclusions
HBV infection can increase the early abortion rate of pregnancy, and the reason may
be related to HBV-infected embryos.
Keywords
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Article info
Publication history
Published online: October 28, 2013
Accepted:
October 1,
2013
Received in revised form:
September 16,
2013
Received:
July 22,
2013
Identification
Copyright
© 2013 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
