The aim of this study was to investigate the incidence, clinicopathological features, and reproductive outcomes of atypical endometrial hyperplasia (AH) in infertile patients. Endometrial carcinoma (EC) or AH are detected at a higher rate among infertile patients. This elevated incidence of EC may be the result of unopposed estrogen stimulation, e.g. ovulation disorders, progesterone deficiency, or polycystic ovaries. Although the safety and efficacy of fertility-preserving therapies have been demonstrated, there are few publications reporting successful pregnancies after this type of treatment [
- Kimming R.
- Strowitzki T.
- Müller-Höcker J.
- Kürzl R.
- Korell M.
- Hepp H.
Conservative treatment of endometrial cancer permitting subsequent triplet pregnancy.
Gynecol Oncol. 1995; 58: 255-257
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- Conservative treatment of endometrial cancer permitting subsequent triplet pregnancy.Gynecol Oncol. 1995; 58: 255-257
- Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women.J Clin Oncol. 2007; 25: 2798-2803
- Fertility-preserving treatment in young women with well-differentiated endometrial carcinoma and severe atypical hyperplasia of endometrium.Fertil Steril. 2009; 92: 2122-2124
- Pregnancy outcomes using assisted reproductive technology after fertility-preserving therapy in patients with endometrial adenocarcinoma or atypical complex hyperplasia.Int J Gynecol Cancer. 2009; 19: 147-151
- Outcome analysis of conservative treatment of well-differentiated endometrial adenocarcinoma and severe atypical hyperplasia in young women.Zhonghua Fu Chan Ke Za Zhe. 2006; 41: 242-245
Published online: October 16, 2013
Received: June 12, 2013
© 2013 Published by Elsevier Inc.