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Review| Volume 178, P27-34, July 2014

Risk factors for the development of stress urinary incontinence during pregnancy in primigravidae: a review of the literature

      Abstract

      The most common type of urinary incontinence (UI) in pregnant women is stress urinary incontinence (SUI). The number of pregnant women with SUI was variable, the prevalence ranged from 18.6% to 75% and increased with gestational age. It can affect the quality of life (QoL) of approximately 54.3% of all pregnant women in four domains including physical activity, travel, social relationships and emotional health. Pregnancy is one of the main risk factors for the development of SUI in young women. Physiological changes during pregnancy, such as increasing pressure of the growing uterus and fetal weight on the pelvic floor muscle (PFM) throughout pregnancy, together with pregnancy-related hormonal changes such as increased progesterone, decreased relaxin, and decreased collagen levels, may lead to reduced strength and supportive and sphincteric function of the PFM. Pregnancy may associate with the reduction of the PFM strength which can develop the SUI. However, the exact causes of pregnancy-related SUI remain unclear. Multiple factors have been found to be associated with the development of SUI during pregnancy. In genetic risk factors, aging is an important role in SUI development. The other risk factors such as obesity, smoking, constipation, pre-pregnancy SUI, gestational diabetes mellitus (GDM), and pelvic floor muscle exercise (PFME) that utilized preventive strategies can reduce SUI in pregnant women. The purpose of this review is to identify the risk factors for the development of SUI in pregnant women. These understanding can be useful for health professions to inform and counsel the pregnant women to prevent and reduce the risk factors that contribute to the development of SUI during pregnancy and postpartum period.

      Keywords

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      References

        • Haylen B.T.
        • de Ridder D.
        • Freeman R.M.
        • et al.
        An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunction.
        Int Urogynecol J. 2010; 21: 5-26
        • Sangsawang B.
        • Sangsawang N.
        Stress urinary incontinence in pregnant women: a review of prevalence, pathophysiology, and treatment.
        Int Urogynecol J. 2013; 24: 901-912
        • Liang C.C.
        • Chang S.D.
        • Lin S.J.
        • Lin Y.J.
        Lower urinary tract symptoms in primiparous women before and during pregnancy.
        Arch Gynecol Obstet. 2012; 285: 1205-1210
        • Fritel X.
        • Fauconnier A.
        • Bader G.
        • et al.
        Diagnosis and management of adult female stress urinary incontinence: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians.
        Eur J Obstet Gynecol Reprod Biol. 2010; 151: 14-19
        • Sharma J.B.
        • Aggarwal S.
        • Singhal S.
        • Kumar S.
        • Roy K.K.
        Prevalence of urinary incontinence and other urological problems during pregnancy: a questionnaire based study.
        Arch Gynecol Obstet. 2008; 279: 845-851
        • Wijma J.
        • Weis Potters A.E.
        • Tinga D.J.
        • Aarnoudse J.G.
        The diagnostic strength of the 24-h pad test for self-reported symptoms of urinary incontinence in pregnancy and after childbirth.
        Int Urogynecol J Pelvic Floor Dysfunct. 2008; 19: 525-530
        • FitzGerald M.P.
        • Graziano S.
        Anatomic and functional changes of the lower urinary tract during pregnancy.
        Urol Clin North Am. 2007; 34: 7-12
        • McKinnie V.
        • Swift S.E.
        • Wang W.
        • et al.
        The effect of pregnancy and mode of delivery on the prevalence of urinary and fecal incontinence.
        Am J Obstet Gynecol. 2005; 193: 512-518
        • Viktrup L.
        The risk of urinary tract symptom five years after the first delivery.
        Neurourol Urodyn. 2002; 21: 2-29
        • Retzky S.S.
        • Rogers Jr., R.M.
        Urinary incontinence in women.
        Clin Symp. 1995; 47: 2-32
        • Morkved S.
        • Salvesen K.A.
        • Bo K.
        • Eik-Nes S.
        Pelvic floor muscle strength and thickness in continent and incontinent nulliparous pregnant women.
        Int Urogynecol J Pelvic Floor Dysfunct. 2004; 15: 384-390
        • Joanna Briggs Institute
        The Joanna Briggs Institute best practice information sheet: the effectiveness of pelvic floor mus-cle exercises on urinary incontinence in women following child-birth.
        Nurs Health Sci. 2011; 13: 378-381
        • Dinc A.
        • Kizilkaya Beji N.
        • Yalcin O.
        Effect of pelvic floor muscle exercises in the treatment of urinary incontinence during pregnancy and the postpartum period.
        Int Urogynecol J Pelvic Floor Dysfunct. 2009; 20: 1223-1231
        • Newman D.K.
        Conservative management of urinary inconti-nence in women.
        Prim Care Update Ob Gyns. 2001; 8: 153-162
        • de Oliveira C.
        • Lopes M.A.
        • Carla Longo e Pereira L.
        • Zugaib M.
        Effects of pelvic floor muscle training during pregnancy.
        Clinics. 2007; 62: 439-446
        • Neumann P.B.
        • Grimmer K.A.
        • Grant R.E.
        • Gill V.A.
        The costs and benefits of physiotherapy as first-line treatment for female stress urinary incontinence.
        Aust N Z J Public Health. 2005; 29: 416-421
        • Hay-Smith J.
        • Mørkved S.
        • Fairbrother K.A.
        • Herbison G.P.
        Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women.
        Cochrane Database Syst Rev. 2008; 4: CD007471
        • Wesnes S.L.
        • Lose G.
        Preventing urinary incontinence during pregnancy and postpartum: a review.
        Int Urogynecol J. 2013; 24: 889-899
        • Wesnes S.L.
        • Rortveit G.
        • Bø K.
        • Hunskaar S.
        Urinary incontinence during pregnancy.
        Obstet Gynecol. 2007; 109: 922-928
        • Zhu L.
        • Li L.
        • Lang J.H.
        • Xu T.
        Prevalence and risk factors for peri and postpartum urinary incontinence in primiparous women in China: a prospective longitudinal study.
        Int Urogynecol J. 2012; 23: 563-572
        • Hvidman L.
        • Foldspang A.
        • Mommsen S.
        • Nielsen J.B.
        Correlates of urinary incontinence in pregnancy.
        Int Urogynecol J Pelvic Floor Dysfunct. 2002; 13: 278-283
        • Rortveit G.
        • Hunskaar S.
        Urinary incontinence and age at the first and last delivery: the Norwegian HUNT/EPINCONT study.
        Am J Obstet Gyn. 2006; 195: 433-438
        • Groutz A.
        • Helpman L.
        • Gold R.
        • Pauzner D.
        • Lessing J.B.
        • Gordon D.
        First vaginal delivery at an older age: does it carry an extra risk for the development of stress urinary incontinence?.
        Neurourol Urodyn. 2007; 26: 779-782
        • Allahdin S.
        • Kambhampati L.
        Stress urinary incontinence in continent primigravidas.
        J Obstet Gynaecol. 2012; 32: 2-5
        • Pandit M.
        • DeLancey J.O.
        • Ashton-Miller J.A.
        • Iyengar J.
        • Blaivas M.
        • Perucchini D.
        Quantification of intramuscular nerves within the female striated urogenital sphincter muscle.
        Obstet Gynecol. 2000; 95: 797-800
        • Perucchini D.
        • DeLancey J.O.
        • Ashton-Miller J.A.
        • Peschers U.
        • Kataria T.
        Age effects on urethral striated muscle. I. Changes in number and diameter of striated muscle fibers in the ventral urethra.
        Am J Obstet Gynecol. 2002; 186: 351-355
        • Rud T.
        Urethral pressure profile in continent women from childhood to old age.
        Acta Obstet Gynecol Scand. 1980; 59: 331-335
        • Dietz H.P.
        • Wilson P.D.
        Childbirth and pelvic floor trauma.
        Best Pract Res Clin Obstet Gynaecol. 2005; 19: 913-924
        • Hijaz A.
        • Sadeghi Z.
        • Byrne L.
        • Hou J.C.
        • Daneshgari F.
        Advanced maternal age as a risk factor for stress urinary incontinence: a review of the literature.
        Int Urogynecol J. 2012; 23: 395-401
        • Lien K.C.
        • Mooney B.
        • DeLancey J.O.
        • Ashton-Miller J.A.
        Levator ani muscle stretch induced by simulated vaginal birth.
        Obstet Gynecol. 2004; 103: 31-40
        • Leijonhufvud A.
        • Lundholm C.
        • Cnattingius S.
        • Granath F.
        • Andolf E.
        • Altman D.
        Risk of surgically managed pelvic floor dysfunction in relation to age at first delivery.
        Am J Obstet Gynecol. 2012; 207: e1-e7
        • Jain P.
        • Parsons M.
        The effects of obesity on the pelvic floor.
        Obs. Gynae. 2011; 13: 133-142
        • Bump R.C.
        • Sugerman H.
        • Fantl J.A.
        • McClish D.M.
        Obesity and lower urinary tract function in women: effect of surgically induced weight loss.
        Am J Obstet Gynecol. 1992; 166: 392-399
        • Eltatawy H.H.
        • Elhawary T.M.
        • Soliman M.G.
        • Taha M.R.
        The link between female obesity and urinary stress incontinence.
        Uro Today Int J. 2011; 4: art 63https://doi.org/10.3834/uij.1944-5784.2011.10.5
        • Burgio K.L.
        • Zyczynski H.
        • Locher J.L.
        • Richter H.E.
        • Redden D.T.
        • Wright K.C.
        Urinary incontinence in the 12-month postpartum period.
        Obstet Gynecol. 2003; 102: 1291-1298
        • Greer W.J.
        • Richter H.E.
        • Bartolucci A.A.
        • Burgio K.L.
        Obesity and pelvic floor disorders: a systematic review.
        Obstet Gynecol. 2008; 112: 341-349
        • Ebbesen M.H.
        • Hannestad Y.S.
        • Midthjell K.
        • Hunskaar S.
        Diabetes and urinary incontinence – prevalence data from Norway.
        Acta Obstet Gynecol Scand. 2007; 86: 1256-1262
        • Hojberg K.E.
        • Salvig J.D.
        • Winslow N.A.
        • Lose G.
        • Secher N.J.
        Urinary incontinence: prevalence and risk factors at 16 weeks of gestation.
        Br J Obstet Gynecol. 1999; 106: 842-850
        • Diez-Itza I.
        • Ibañez L.
        • Arrue M.
        • Paredes J.
        • Murgiondo A.
        • Sarasqueta C.
        Influence of maternal weight on the new onset of stress urinary incontinence in pregnant women.
        Int Urogynecol J Pelvic Floor Dysfunct. 2009; 20: 1259-1263
        • Arrue M.
        • Ibañez L.
        • Paredes J.
        • et al.
        Stress urinary incontinence six months after first vaginal delivery.
        Eur J Obstet Gynecol Reprod Biol. 2010; 150: 210-214
        • Scarpa K.P.
        • Herrmann V.
        • Palma P.C.
        • Riccetto C.L.
        • Morais S.S.
        Prevalence and correlates of stress urinary incontinence during pregnancy: a survey at UNICAMP Medical School, São Paulo, Brazil.
        Int Urogynecol J Pelvic Floor Dysfunct. 2006; 17: 219-223
        • Chiarelli P.
        • Campbell E.
        Incontinence during pregnancy. Prevalence and opportunities for continence promotion.
        Aust N Z J Obstet Gynaecol. 1997; 37: 66-73
        • Subak L.L.
        • Whitcomb E.
        • Shen H.
        • Saxton J.
        • Vittinghoff E.
        • Brown J.S.
        Weight loss: a novel and effective treatment for urinary incontinence.
        J Urol. 2005; 174: 190-195
        • Auwad W.
        • Steggles P.
        • Bombieri L.
        • Waterfield M.
        • Wilkin T.
        • Freeman R.
        Moderate weight loss in obese women with urinary incontinence: a prospective longitudinal study.
        Int Urogynecol J Pelvic Floor Dysfunct. 2008; 19: 1251-1259
        • Subak L.L.
        • Johnson C.
        • Whitcomb E.
        • Boban D.
        • Saxton J.
        • Brown J.S.
        Does weight loss improve incontinence in moderately obese women?.
        Int Urogynecol J Pelvic Floor Dysfunct. 2002; 13: 40-43
        • Deitel M.
        • Stone E.
        • Kassam H.A.
        • Wilk E.J.
        • Sutherland D.J.
        Gynecologic-obstetric changes after loss of massive excess weight following bariatric surgery.
        J Am Coll Nutr. 1988; 7: 147-153
        • Brown J.S.
        • Wing R.
        • Barrett-Connor E.
        • et al.
        Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program. Diabetes Prevention Program Research Group.
        Diabetes Care. 2006; 29: 385-390
      1. Rasmussen K.M. Yaktine A.L. Weight gain during pregnancy: reexamining the guidelines. Academy Press, Washington: National2009
        • Hannestad Y.S.
        • Rortveit G.
        • Daltveit A.K.
        • Hunskaar S.
        Are smoking and other lifestyle factors associated with female urinary incontinence? The Norwegian EPINCONT.
        Br J Obstet Gynaecol. 2003; 110: 247-254
        • Bump R.C.
        • McClish D.M.
        Cigarette smoking and pure genuine stress incontinence of urine: a comparison of risk factors and determinants between smokers and nonsmokers.
        Am J Obstet Gynecol. 1994; 170: 579-582
        • Thom D.H.
        • Rortveit G.
        Prevalence of postpartum urinary incontinence: a systematic review.
        Acta Obstet Gynecol Scand. 2010; 89: 1511-1522
        • Bonapace Jr, E.S.
        • Fisher R.S.
        Constipation and diarrhea in pregnancy.
        Gastroenterol Clin North Am. 1998; 27: 197-211
        • van Brummen H.J.
        • Bruinse H.W.
        • van de Pol G.
        • Heintz A.P.
        • van der Vaart C.H.
        Defecatory symptoms during and after the first pregnancy: prevalences and associated factors.
        Int Urogynecol J Pelvic Floor Dysfunct. 2006; 17: 224-230
        • Marshall K.
        • Thompson K.A.
        • Walsh D.M.
        • Baxter G.D.
        Incidence of urinary incontinence and constipation during pregnancy and postpartum: survey of current findings at the Rotunda Lying-in Hospital.
        Br J Obstet Gynaecol. 1998; 105: 400-402
        • Müller-Lissner S.A.
        • Kamm M.A.
        • Scarpignato C.
        • Wald A.
        Myths and misconceptions about chronic constipation.
        Am J Gastroenterol. 2005; 100: 232-242
        • West L.
        • Warren J.
        • Cutts T.
        Diagnosis and management of irritable bowel syndrome, constipation, and diarrhea in pregnancy.
        Gastroenterol Clin North Am. 1992; 21: 793-802
        • Amselem C.
        • Puigdollers A.
        • Azpiroz F.
        • et al.
        Constipation: a potential cause of pelvic floor damage?.
        Neurogastroenterol Motil. 2010; 22: 150-153
        • Bump R.C.
        • Norton P.A.
        Epidemiology and natural history of pelvic floor dysfunction.
        Obstet Gynecol Clin North Am. 1998; 25: 723-746
        • Bradley C.S.
        • Kennedy C.M.
        • Turcea A.M.
        • Rao S.S.
        • Nygaard I.E.
        Constipation in pregnancy: prevalence, symptoms, and risk factors.
        Obstet Gynecol. 2007; 110: 1351-1357
        • Martins G.
        • Soler Z.A.
        • Cordeiro J.A.
        • Amaro J.L.
        • Moore K.N.
        Prevalence and risk factors for urinary incontinence in healthy pregnant Brazilian women.
        Int Urogynecol J. 2010; 21: 1271-1277
        • Kocaöz S.
        • Talas M.S.
        • Atabekoğlu C.S.
        Urinary incontinence in pregnant women and their quality of life.
        J Clin Nurs. 2010; 19: 3314-3323
        • Fritel X.
        • Fauconnier A.
        • Levet C.
        • Bénifla J.L.
        Stress urinary incontinence 4 years after the first delivery: a retrospective cohort survey.
        Acta Obstet Gynecol Scand. 2004; 83: 941-945
        • Landon C.R.
        • Crofts C.E.
        • Smith A.R.B.
        • Trowbridge E.A.
        Mechanical properties of fascia during pregnancy: a possible factor in the development of stress incontinence of urine.
        Contemp Rev Obstet Gynaecol. 1990; 2: 40-46
        • Brown S.J.
        • Donath S.
        • MacArthur C.
        • McDonald E.A.
        • Krastev A.H.
        Urinary incontinence in nulliparous women before and during pregnancy: prevalence, incidence, and associated risk factors.
        Int Urogynecol J. 2010; 21: 193-202
        • Lifford K.L.
        • Curhan G.C.
        • Hu F.B.
        • Barbieri R.L.
        • Grodstein F.
        Type 2 diabetes mellitus and risk of developing urinary incontinence.
        J Am Geriatr Soc. 2005; 53: 1851-1857
        • Melville J.L.
        • Katon W.
        • Delaney K.
        • Newton K.
        Urinary incontinence in US women: a population-based study.
        Arch Intern Med. 2005; 165: 537-542
        • Saydah S.H.
        • Chandra A.
        • Eberhardt M.S.
        Pregnancy experience among women with and without gestational diabetes in the U.S., 1995 National survey of family growth.
        Diabetes Care. 2005; 28: 1035-1040
        • Brown J.S.
        • Nyberg L.M.
        • Kusek J.W.
        • Burgio K.L.
        • Diokno A.C.
        Proceedings of the national institute of diabetes and digestive and kidney diseases international symposium on epidemiologic issues in urinary incontinence in women.
        Am J Obstet Gynecol. 2003; 188: S77-S88
        • Kim C.
        • McEwen L.N.
        • Sarma A.V.
        • Piette J.D.
        • Herman W.H.
        Stress urinary incontinence in women with a history of gestational diabetes mellitus.
        J Womens Health. 2008; 17: 783-792
        • Chuang C.M.
        • Lin I.F.
        • Horng H.C.
        • Hsiao Y.H.
        • Shyu I.L.
        • Chou P.
        The impact of gestational diabetes mellitus on postpartum urinary incontinence: a longitudinal cohort study on singleton pregnancies.
        Br J Obstet Gynecol. 2012; 119: 1334-1343
        • Price N.
        • Dawood R.
        • Jackson S.R.
        Pelvic floor exercise for urinary incontinence: a systematic literature review.
        Maturitas. 2010; 67: 309-315
        • Bø K.
        Pelvic floor muscle training is effective in treatment of female stress urinary incontinence, but how does it work?.
        Int Urogynecol J Pelvic Floor Dysfunct. 2004; 15: 76-84
        • Holroy-Ledue J.M.
        • Straus S.E.
        Management of urinary incontinence in women.
        JAMA. 2004; 291: 996-999
        • Mason L.
        • Glenn S.
        • Walton Hughes I.C.
        The instruction in pelvic floor exercise provided to women during pregnancy or following delivery.
        Midwifery. 2001; 17: 55-64
        • Bø K.
        • Haakstad L.A.
        Is pelvic floor muscle training effective when taught in a general fitness class in pregnancy? A randomised controlled trial.
        Physiotherapy. 2011; 97: 190-195
        • Sampselle C.M.
        • Miller J.M.
        • Mims B.L.
        • Delancey J.O.L.
        • Ashton-Miller J.A.
        • Antonakos C.L.
        Effect of pelvic muscle exercise on transient incontinence during pregnancy and after birth.
        Obstet Gynecol. 1998; 91: 406-412
        • Kocaöz S.
        • Eroğlu K.
        • Sivaslıoğlu A.A.
        Role of pelvic floor muscle exercises in the prevention of stress urinary incontinence during pregnancy and the postpartum period.
        Gynecol Obstet Invest. 2013; 75: 34-40
        • Mason L.
        • Roe B.
        • Wong H.
        • Davies J.
        • Bamber J.
        The role of antenatal pelvic floor muscle exercises in prevention of postpartum stress incontinence: a randomised controlled trial.
        J Clin Nurs. 2010; 19: 2777-2786
        • Boyle R.
        • Hay-Smith E.J.
        • Cody J.D.
        • Mørkved S.
        Pelvic floor muscle training for prevention and treatment of urinary and fecal incontinence in antenatal and postnatal women: a short version Cochrane review.
        Neurourol Urodyn. 2013; https://doi.org/10.1002/nau.22402
        • Sievert K.D.
        • Amend B.
        • Toomey P.A.
        • et al.
        Can we prevent incontinence? ICI-RS 2011.
        Neurourol Urodyn. 2012; 31: 390-399
        • Wijma J.
        • Weis Potters A.E.
        • de Wolf B.T.H.M.
        • Tinga D.J.
        • Aarnoudse J.G.
        Anatomical and functional changes in the lower urinary tract during pregnancy.
        Br J Obstet Gynaecol. 2001; 108: 726-732
        • Jundt K.
        • Scheer I.
        • Schiessl B.
        • Karl K.
        • Friese K.
        • Peschers U.M.
        Incontinence, bladder neck mobility, and sphincter ruptures in primiparous women.
        Eur J Med Res. 2010; 15: 246-252
        • Chaliha C.
        • Bland J.M.
        • Monga A.
        • Stanton S.L.
        • Sultan A.H.
        Pregnancy and derivery: a urodynamic viewpoint.
        Br J Obstet Gynaecol. 2000; 107: 1354-1359
        • vanGeelen J.M.
        • Lemmens W.A.
        • Eskes T.K.
        • Martin Jr., C.B.
        The urethral pressure profile in pregnancy and after delivery in healthy nulliparous women.
        Am J Obstet Gynecol. 1982; 144: 636-649
        • Swift S.E.
        • Ostergard D.R.
        Effects of progesterone on the urinary tract.
        Int Urogynecol J. 1993; 4: 232-236
        • Hilton P.
        • Dolan L.M.
        Pathophysiologyof urinary incontinence and pelvic organ prolapse.
        Br J Obstet Gynaecol. 2004; 1: 5-9
        • Kristiansson P.
        • Samuelsson E.
        • Schoultz B.
        • Svardsudd K.
        Reproductive hormones and stress urinary incontinence in pregnancy.
        Acta Obstet Gynecol Scand. 2001; 80: 1125-1130
        • Keane D.P.
        • Sims T.J.
        • Abrams P.
        • Bailey A.J.
        Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence.
        Br J Obstet Gynaecol. 1997; 104: 994-998
        • Hilde G.
        • Stær-Jensen J.
        • Ellström Engh M.
        • Brækken I.H.
        • Bø K.
        Continence and pelvic floor status in nulliparous women at midterm pregnancy.
        Int Urogynecol J. 2012; 23: 1257-1263