Subchorionic hematoma occurs more frequently in in vitro fertilization pregnancy



      Obstetric complications occur more frequently in pregnancies after in vitro fertilization (IVF). We attempted to determine the correlation between subchorionic hematoma and IVF pregnancies.

      Study design

      We analyzed 194 pregnancies achieved by infertility treatment between January 2008 and February 2012 at our hospital. Among these, 67 were achieved by IVF and 127 by non-IVF approaches. We compared the frequency of subchorionic hematoma between the groups and examined the risk factors for subchorionic hematoma in the IVF group.


      No significant differences regarding age and the number of uterine surgery were observed between the groups. The duration of infertility was longer, parity and the rate of luteal support were higher in the IVF group compared with that in the non-IVF group. The frequency of subchorionic hematoma was significantly higher in the IVF group (22.4%) than that in the non-IVF group (11%) (P = 0.035). Univariate analysis in the IVF group demonstrated that frozen–thawed embryo transfer (OR, 6.18; 95% CI, 1.7–22.4), parity ≥ 1 (OR, 3.67; 95% CI, 1.0–13.2) and blastocyst transfer (OR, 3.75; 95% CI, 1.1–13.3) were risk factors for the subchorionic hematoma.


      The frequency of subchorionic hematoma is high in IVF pregnancies, and frozen–thawed embryo transfer, parity ≥ 1, and blastocyst transfer may contribute to subchorionic hematoma onset.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • Healy D.L.
        • Breheny S.
        • Halliday J.
        • et al.
        Prevalence and risk factors for obstetric hemorrhage in 6730 singleton births after assisted reproductive technology in Victoria Australia.
        Hum Reprod. 2010; 25: 265-274
        • Esh-Broder E.
        • Ariel I.
        • Abas-Bashir N.
        • Bdolah Y.
        • Celnikier D.H.
        Placenta accreta is associated with IVF pregnancies: a retrospective chart review.
        BJOG. 2011; 118: 1084-1089
        • Smithers P.R.
        • Halliday J.
        • Hale L.
        • Talbot J.M.
        • Breheny S.
        • Healy D.
        High frequency of Cesarean section: antepartum hemorrhage, placenta previa, and preterm delivery in in-vitro fertilization twin pregnancies.
        Fertil Steril. 2003; 80: 666-668
        • Romundstad L.B.
        • Romundstad P.R.
        • Sunde A.
        • von Düring V.
        • Skjaerven R.
        • Vatten L.J.
        Increased risk of placenta previa in pregnancies following IVF/ICSI; a comparison of ART and non-ART pregnancies in the same mother.
        Hum Reprod. 2006; 21: 2353-2358
        • Sazonova A.
        • Källen K.
        • Thurin-Kjellberg A.
        • Wennerholm U.B.
        • Bergh C.
        Factors affecting obstetrics outcome of singletons born after IVF.
        Hum Reprod. 2011; 26: 2878-2886
        • Shapiro B.S.
        • Daneshmand S.T.
        • Garner F.C.
        • Aguirre M.
        • Hudson C.
        • Thomas S.
        Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen–thawed embryo transfer in normal responders.
        Fertil Steril. 2011; 96: 344-348
        • Tuuli M.G.
        • Norman S.M.
        • Odibo A.O.
        • Macones G.A.
        • Cahill A.G.
        Perinatal outcomes in women with subchorionic hematoma: a systematic review and meta-analysis.
        Obstet Gynecol. 2011; 117: 1205-1212
        • Nagy S.
        • Bush M.
        • Stone J.
        • Lapinski R.H.
        • Gardó S.
        Clinical significance of subchorionic and retroplacental hematomas detected in the first trimester of pregnancy.
        Obstet Gynecol. 2003; 102: 94-100
        • Sharma G.
        • Kalish R.B.
        • Chasen S.T.
        Prognostic factors associated with antenatal subchorionic echolucencies.
        Am J Obstet Gynecol. 2003; 189: 994-996
        • Norman S.M.
        • Odibo A.O.
        • Macones G.A.
        • Dicke J.M.
        • Crane J.P.
        • Cahill A.G.
        Ultrasound-detected subchorionic hemorrhage and the obstetric implications.
        Obstet Gynecol. 2010; 116: 311-315
        • Maso G.
        • D’Ottavio G.
        • De Seta F.
        • Sartore A.
        • Piccoli M.
        • Mandruzzato G.
        First-trimester intrauterine hematoma and outcome of pregnancy.
        Obstet Gynecol. 2005; 105: 339-344
        • Horcajadas J.A.
        • Riesewijk A.
        • Polman J.
        • et al.
        Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles.
        Hum Reprod. 2005; 11: 195-205
        • Maheshwari A.
        • Pandey S.
        • Shetty A.
        • Hamilton M.
        • Bhattacharya S.
        Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis.
        Fertil Steril. 2012; 98: v368-v377
        • Sazonova A.
        • Källen K.
        • Thurin-Kjellberg A.
        • Wennerholm U.B.
        • Bergh C.
        Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos.
        Hum Reprod. 2012; 27: 1343-1350
        • Ishihara O.
        • Araki R.
        • Kuwahara A.
        • Itakura A.
        • Saito H.
        • Adamson G.D.
        Impact of frozen–thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan.
        Fertil Steril. 2014; 101: 128-133
        • Kuno S.
        • Yamamoto T.
        Pregnancy induced hypertension.
        Essent Perinatal Med. 2011; 41: 232-234
        • Fernando D.
        • Halliday J.L.
        • Breheny S.
        • Healy D.L.
        Outcomes of singleton births after blastocyst versus nonblastocyst transfer in assisted reproductive technology.
        Fertil Steril. 2012; 97: 579-584
        • Dar S.
        • Librach C.L.
        • Gunby J.
        • Bissonnette F.
        • Cowan L.
        Increased risk of preterm birth in singleton pregnancies after blastocyst versus Day 3 embryo transfer: Canadian ART Register (CARTR) analysis.
        Hum Reprod. 2013; 28: 924-928