Abstract
Objective
Centrosome aberrations and cell-cycle deregulations have important implications for
the development of endometrial carcinoma. AURKA, BRCA1, CCNE1 and CDK2 genes play pivotal roles in centrosome duplication and cell-cycle regulation. This
study aimed to investigate whether genetic polymorphisms in these four genes may contribute
to endometrial carcinoma susceptibility and progression in Chinese Han women.
Study design
: A total of twenty-two single nucleotide polymorphisms (SNPs) were selected according
to the public HapMap database (HapMap Data Release #27; Chinese Beijing population),
and genotyped using TaqMan Realtime PCR method in 530 endometrial adenocarcinoma cases
and 825 age-matched controls from Chinese Han women. Then, haplotype blocks were reconstructed
according to our genotyping data.
Results
For AURKA, the rs911162 was associated with increased risk of endometrial carcinoma [in co-dominant
model: adjusted odds ratio (aOR) = 4.92, 95% CI = 1.24–19.55, P = 0.0235]. The haplotype GA (rs6064391 + rs911162) in block 1 of AURKA was also associated with increased risk of endometrial carcinoma (aOR = 1.25, 95% CI = 1.07–2.06, P = 0.0189). For BRCA1, the minor allele homozygotes of rs8067269 could decrease the risk of endometrial
carcinoma (in co-dominant models: aOR = 0.52, 95% CI = 0.34–0.80, P = 0.0032), so was the haplotype CTCAG (rs8176323 + rs8176199 + rs3737559 + rs8067269 + rs2070833) (aOR = 0.69, 95% CI = 0.50–0.95, P = 0.0234). Moreover, we found several associations between genetic variations in CCNE1, BRCA1 and AURKA and clinicopathological parameters.
Conclusions
This study indicates that genetic polymorphisms of AURKA, BRCA1 and CCNE1 may contribute to endometrial carcinoma susceptibility or progression in Chinese
Han women.
Keywords
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Article info
Publication history
Published online: November 18, 2014
Accepted:
November 11,
2014
Received in revised form:
October 13,
2014
Received:
December 4,
2013
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
