Abstract
Introduction and hypothesis
The aim of this study was to evaluate the effectiveness of transcutaneous posterior
tibial nerve stimulation (T.C. PTNS) versus extended release oxybutynin (E.R.O.) in
patients with overactive bladder.
Materials and methods
Seventy female patients were randomized to receive either 10 mg E.R.O. daily or T.C. PTNS, using a TENS machine program with the 20 Hz, 200 cycles/s, and normal stimulation setting for two 30-min sessions, each week for a
12-week period. Pre-treatment and after the 12-week intervention, each patient completed
a 3-day voiding diary and a self-report quality of life questionnaire (OAB-q). Statistical
analysis was performed using Stata V12.1.
Results
Sixty-four patients completed the treatment protocol. There were no significant differences
between study groups in terms of age, body mass index, past hormone replacement therapy,
smoking habits, menopause status, and parity. Prior to treatment, there were also
no significant differences in the analysis of the 3-day voiding diary or in the OAB-q
questionnaire results. Following the 12-week study, there was a statistically significant
reduction in frequency of urination, urgency episodes, and urge incontinent episodes
compared to pre-treatment values. However, there were no significant differences in
these values between intervention groups after 12-weeks of therapy. There was a similar
improvement in OAB-q scores in both treatment groups following therapy, and the T.C.
PTNS group showed a statistically significant improvement over the E.R.O. in domain
2 of the OAB-q questionnaire. The other two domains showed similar improvement in
both study groups.
Conclusion
T.C. PTNS and E.R.O. demonstrated similar improvements in subjects with OAB in a 12-week
study.
Keywords
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Article info
Publication history
Published online: October 15, 2015
Accepted:
September 17,
2015
Received in revised form:
September 2,
2015
Received:
April 3,
2015
Identification
Copyright
© 2015 Published by Elsevier Inc.
