Abstract
Objective
The objective of the present study was to compare the accuracy of SONOBREAST for the
prediction of malignancy in solid breast nodules detected at ultrasonography with
that of the BI-RADS system and to assess the agreement between these two methods.
Study design
This prospective study included 274 women and evaluated 500 breast nodules detected
at ultrasonography. The probability of malignancy was calculated based on the SONOBREAST
model, available at www.sonobreast.com.br, and on the BI-RADS system, with results being compared with the anatomopathology
report.
Results
The lesions were considered suspect in 171 cases (34.20%), according to both SONOBREAST
and BI-RADS. Agreement between the methods was perfect, as shown by a Kappa coefficient
of 1 (p < 0.001). SONOBREAST and BI-RADS proved identical insofar as sensitivity (95.40%), specificity
(78.69%), positive predictive value (48.54%), negative predictive value (98.78%) and
accuracy (81.60%) are concerned. With respect to the categorical variables (BI-RADS
categories 3, 4 and 5), the area under the receiver operating characteristic (ROC)
curve was 94.41 for SONOBREAST (range 92.20–96.62) and 89.99 for BI-RADS (range 86.60–93.37).
Conclusions
The accuracy of the SONOBREAST model is identical to that found with BI-RADS when
the same parameters are used with respect to the cut-off point at which malignancy
is suspected. Regarding the continuous probability of malignancy with BI-RADS categories
3, 4 and 5, SONOBREAST permits a more precise and individualized evaluation.
Keywords
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Article info
Publication history
Published online: September 29, 2015
Accepted:
September 21,
2015
Received in revised form:
September 13,
2015
Received:
April 4,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
