Abstract
Objective
Polycystic ovarian syndrome (PCOS) is a complex and multifactorial disorder believed
to be the consequence of a complex interaction between genetic, immunological, and
environmental factors. The main aim of this study was to investigate the association
of Connexin37 (Cx37)/Gap junction alpha 4 (GJA4) gene C1019T single nucleotide polymorphism (SNP) with the susceptibility to polycystic ovarian
syndrome (PCOS) in South Indian women.
Study design
This study comprises 98 PCOS patients and 100 healthy women without PCOS of South
Indian origin. We genotyped total of seventeen selected Cx37 SNPs including C1019T (rs1764391) by polymerase chain reaction and sequencing analysis. The genotype frequency
and allele distributions of cases and controls were analyzed using Fisher's exact
test.
Results
The genotype and allele frequencies of the C1019T polymorphism significantly differ between cases and controls. The frequencies of
C/C genotype (P = 0.009) and ‘C’ allele (P = 0.002) of the C1019T polymorphism showed a significant prevalence in cases compared to controls.
Conclusion
Our findings suggest that the Cx37 C1019T variation may contribute to the risk of PCOS in the South Indian women.
Keywords
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Article info
Publication history
Published online: November 21, 2015
Accepted:
November 12,
2015
Received in revised form:
November 5,
2015
Received:
July 15,
2015
Identification
Copyright
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
