Past studies have clearly shown the existence of a spectrum of endometrial progesterone responses in neonatal endometrium, varying from proliferation to full decidualization with menstrual-like shedding. The bleedings represent, similar to what occurs in adult menstruation, a progesterone withdrawal bleeding. Today, the bleeding is completely neglected and considered an uneventful episode of no clinical significance. Yet clinical studies have linked the risk of bleeding to a series of events indicating fetal distress. The potential link between the progesterone response and major adolescent disorders requires to be investigated by prospective studies.
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- Neonatal uterine bleeding as antecedent of pelvic endometriosis.Hum Reprod. 2013; 28: 2893-2897
- Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis.Mol Hum Reprod. 2014; 20: 591-598
- Die Fötale Menstruation und ihre Bedeutung [The fetal menstruation and its meaning] Proc Versammlung Deutscher Naturvorscher und Aertze in Breslau (VII.76).Berliner Klin Wochenschr. 1904; 48: 1254-1256
Novak E. Menstruation and its disorders. Forgotten Books; 2013 [originally published in 1921].
- Observations on the endometrium and ovary in the newborn.Pediatrics. 1955; 16: 445-460
- Crise génitale du nouveau-né Répercussion de certains facteurs maternels ou gravidiques sur la fréquence des métrorragies néonatales [Genital crisis in the newborn. Repercussion of certain maternal or pregnancy factors on the frequency of neonatal metrorrhagia].Arch Fr Pediatr. 1964; 21: 819-827
- Uterino krvavljenje u novorodene dece [Uterine hemorrhage in newborn infants].Jugoslavenska Ginekol Perinatol. 1985; 25: 89-91
- Low birth weight is strongly associated with the risk of deep infiltrating endometriosis: results of a 743 case-control study.PLoS ONE. 2015; 10 (art. no. e0117387)
- In utero exposures and the incidence of endometriosis.Fertil Steril. 2004; 82: 1501-1508
- Clinical diagnosis of pelvic endometriosis: a scoping review.BMC Women's Health. 2015; 15 (art. no. 39)
- In utero exposures and endometriosis: the Endometriosis, Natural History, Disease Outcome (ENDO) study.Fertil Steril. 2013; 99: 790-795
- Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion.Hum Reprod. 2013; 28: 2026-2031
- The potential perinatal origin of placentation disorders in the young primigravida.Am J Obstet Gynecol. 2015; 212: 580-585
- Is teenage pregnancy an obstetric risk in a welfare society? A population-based study in Finland, from 2006 to 2011.Brit Med J Open. 2013; 3 (e003225)
Published online: November 24, 2015
Accepted: November 17, 2015
Received: September 3, 2015
© 2015 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.