Abstract
Introduction
Endometriosis is a multifactorial benign gynecologic disorder, characterized by the
ectopic growth of misplaced endometrial cells with complex genetic inheritance and
changing of some immune based factors and also shares some autoimmune characteristics.
However, it is not clear yet that how and when these immunological factors affect
the initiation or progression of the disease. It has been shown that STAT4 is a predisposing gene in the development of some autoimmune diseases.
Method
The study group comprised 114 patients with endometriosis and 92 sex-, age-, and ethnicity-matched
healthy controls of Iranian ancestry. Four SNPs (rs7574865, rs7601754, rs7582694 and
rs11889341) were genotyped using the MGB TaqMan.
Results
A significant association in rs7582694 between C allele (P = 0.002, OR = 1.986, 95% CI: 1.262–3.126) and endometriosis was found in our study, while the G
allele (P = 0.002, OR = 0.0503, 95% CI: 0.319–0.792) was significantly decreased in the patients population.
The GC genotype (P = 0.004, OR = 2.234, 95% CI: 1.301–4.150) was also significantly overrepresented in the patients
with endometriosis, while the frequency of GG genotype was significantly lower in
the patient group, compared to the controls (P = 0.007, OR = 0.457, 95% CI: 0.256–0.813).
Conclusions
Our results for the first time showed a significant association between rs7582694
alleles and genotypes and susceptibility to endometriosis in a population.
Keywords
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Article info
Publication history
Published online: May 13, 2016
Accepted:
May 4,
2016
Received in revised form:
May 1,
2016
Received:
January 12,
2016
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
