Advertisement
Research Article| Volume 209, P46-49, February 2017

Adolescent endometriosis

      Abstract

      Endometriosis is a common finding in adolescents who have a history of chronic pelvic pain or dysmenorrhoea resistant to medical treatment, however the exact prevalence is unknown. Both early/superficial and advanced forms of endometriosis are found in adolescents, including ovarian endometriomas and deep endometriotic lesions. Whilst spontaneous resolution is possible, recent reports suggest that adolescent endometriosis can be a progressive condition, at least in a significant proportion of cases. It is also claimed that deep endometriosis has its roots in adolescence. Optimum treatment is far from clear and long term recurrence is still a significant problem. The most frequently reported treatment approach in the published literature is a combination of surgery and postoperative hormonal treatment with the combined oral contraceptives, progestins, levonorgestrel intrauterine system or gonadotrophin releasing hormone analogues. Use of gonadotrophin releasing hormone analogues and long term progestins should be carefully considered due to concerns over continuing bone formation in this age group. There is currently no consensus as to whether surgery should be avoided as much as possible to prevent multiple operations in the long term, or surgical treatment should be considered at an early stage before more severe lesions develop. Further research is required to determine which approach would offer a better long term outcome.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      References

        • Attaran M.
        • Falcone T.
        Adolescent endometriosis.
        J Minim Invasive Gynecol. 2015; 22: 705-706
        • D’Hooghe T.M.
        • Debrock S.
        • Hill J.A.
        • Meuleman C.
        Endometriosis and subfertility: is the relationship resolved?.
        Semin Reprod Med. 2003; 21: 243-254
        • Fauconnier A.
        • Chapron C.
        Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications.
        Hum Reprod Update. 2005; 11: 595-606
        • Janssen E.B.
        • Rijkers A.C.
        • Hoppenbrouwers K.
        • Meuleman C.
        • D’Hooghe T.M.
        Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review.
        Hum Reprod Update. 2013; May
        • Laufer M.R.
        • Goitein L.
        • Bush M.
        • Cramer D.W.
        • Emans S.J.
        Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy.
        J Pediatr Adolesc Gynecol. 1997; 10: 199-202
        • Reese K.A.
        • Reddy S.
        • Rock J.A.
        Endometriosis in an adolescent population: the Emory experience.
        J Pediatr Adolesc Gynecol. 1996; 9: 125-128
        • Mavrelos D.
        • Saridogan E.
        Therapeutic approach to dysmenorrhoea.
        Prescriber. 2013;
        • Haas D.
        • Chvatal R.
        • Reichert B.
        • et al.
        Endometriosis: a premenopausal disease? Age pattern in 42,079 patients with endometriosis.
        Arch Gynecol Obstet. 2012; 286: 667-670
        • Treloar S.A.
        • Bell T.A.
        • Nagle C.M.
        • Purdie D.M.
        • Green A.C.
        Early menstrual characteristics associated with subsequent diagnosis of endometriosis.
        Am J Obstet Gynecol. 2010; 202: 534-536
        • Nnoaham K.E.
        • Webster P.
        • Kumbang J.
        • Kennedy S.H.
        • Zondervan K.T.
        Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case–control studies.
        Fertil Steril. 2012; 98: 702-712
        • Audebert A.
        • Lecointre L.
        • Afors K.
        • Koch A.
        • Wattiez A.
        • Akladios C.
        Adolescent endometriosis: report of a series of 55 cases with a focus on clinical presentation and long-term issues.
        J Minim Invasive Gynecol. 2015; 22: 834-840
        • Roman J.D.
        Adolescent endometriosis in the Waikato region of New Zealand – a comparative cohort study with a mean follow-up time of 2.6 years.
        Aust N Z J Obstet Gynaecol. 2010; 50: 179-183
        • Yang Y.
        • Wang Y.
        • Yang J.
        • Wang S.
        • Lang J.
        Adolescent endometriosis in China: a retrospective analysis of 63 cases.
        J Pediatr Adolesc Gynecol. 2012; 25: 295-299
        • Brosens I.
        • Gordts S.
        • Benagiano G.
        Endometriosis in adolescents is a hidden, progressive and severe disease that deserves attention, not just compassion.
        Hum Reprod. 2013; June
        • Yeung Jr., P.
        • Sinervo K.
        • Winer W.
        • Albee Jr., R.B.
        Complete laparoscopic excision of endometriosis in teenagers: is postoperative hormonal suppression necessary?.
        Fertil Steril. 2011; 95: 1909-1912
        • Stavroulis A.I.
        • Saridogan E.
        • Creighton S.M.
        • Cutner A.S.
        Laparoscopic treatment of endometriosis in teenagers.
        Eur J Obstet Gynecol Reprod Biol. 2006; 125: 248-250
        • Davis G.D.
        • Thillet E.
        • Lindemann J.
        Clinical characteristics of adolescent endometriosis.
        J Adolesc Health. 1993; 14: 362-368
        • Vicino M.
        • Parazzini F.
        • Cipriani S.
        • Frontino G.
        Endometriosis in young women: the experience of GISE.
        J Pediatr Adolesc Gynecol. 2010; 23: 223-225
        • Hans Evers J.L.
        Is adolescent endometriosis a progressive disease that needs to be diagnosed and treated?.
        Hum Reprod. 2013; 28: 2023
        • Chapron C.
        • Lafay-Pillet M.C.
        • Monceau E.
        • et al.
        Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis.
        Fertil Steril. 2011; 95: 877-881
        • Dunselman G.A.
        • Vermeulen N.
        • Becker C.
        • et al.
        ESHRE guideline: management of women with endometriosis.
        Hum Reprod. 2014; 29: 400-412
        • Kennedy S.
        • Bergqvist A.
        • Chapron C.
        • et al.
        ESHRE guideline for the diagnosis and treatment of endometriosis.
        Hum Reprod. 2005; 20: 2698-2704
        • Divasta A.D.
        • Laufer M.R.
        The use of gonadotropin releasing hormone analogues in adolescent and young patients with endometriosis.
        Curr Opin Obstet Gynecol. 2013; 25: 287-292
        • National Institute for Health and Clinical Excellence
        Long-acting reversible contraception: the effective and appropriate use of long-acting reversible contraception.
        RCOG Press, London2005 (Ref Type: Generic)
        • Bayer L.L.
        • Hillard P.J.
        Use of levonorgestrel intrauterine system for medical indications in adolescents.
        J Adolesc Health. 2013; 52: S54-S58
        • Dun E.C.
        • Kho K.A.
        • Morozov V.V.
        • Kearney S.
        • Zurawin J.L.
        • Nezhat C.H.
        Endometriosis in adolescents.
        JSLS. 2015; 19
        • Tandoi I.
        • Somigliana E.
        • Riparini J.
        • Ronzoni S.
        • Vigano’ P.
        • Candiani M.
        High rate of endometriosis recurrence in young women.
        J Pediatr Adolesc Gynecol. 2011; 24: 376-379