Abstract
Objectives
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive
age. It can affect various organ systems, and respiratory mucosa has been reported
as being hormone responsive.
Study design
A case-control study consisting of 50 women with PCOS and 30 control subjects matched
for age and body mass index was conducted, in order to investigate nasal mucociliary
clearance time (NMCT) in patients with PCOS. Serum basal hormonal-biochemical parameters
and NMCT were evaluated on menstrual cycle days 2–5 for all participants.
Results
The mean NMCT in PCOS and control groups was 10.45 ± 2.88 and 6.92 ± 1.78, respectively (p = 0.0001). A significant positive correlation was found between NMCT and duration of
disease (r = 0.52; p = 0.001), serum total testosterone level (r = 0.28; p = 0.04), and luteinizing hormone/follicle stimulating hormone (r = 0.29; p = 0.04).
Conclusions
Our findings indicate that PCOS is associated with altered NMCT. Prolonged NMCT predisposes
patients to respiratory tract and middle ear infections, and clinicians should be
aware of this.
Keywords
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References
- The prevalence and features of the polycystic ovary syndrome in an unselected population.J Clin Endocrinol Metab. 2004; 89: 2745-2749
- Polycystic ovary syndrome.Best Pract Res Clin Obstet Gynaecol. 2008; 22: 261-274
- The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria.Hum Reprod. 2010; 25: 544-551
- Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular disease.J Clin Endocrinol Metab. 2004; 89: 2160-2165
- Insulin resistance, hypersecretion of LH, and a dual-defect hypothesis for the pathogenesis of polycystic ovary syndrome.Obstet Gynecol. 1994; 84: 613-621
- Human ovarian theca cells in culture.Trends Endocrinol Metab. 2006; 17: 65-71
- Extended high frequency audiometry in polycystic ovary syndrome.Sci World J. 2013; 2013: 482689
- Does menopause effect nasal mucociliary clearance time?.Eur Arch Otorhinolaryngol. 2015; 272: 363-366
- Prospective study on the cytological aspects of the nasal respiratory epithelium in premenopausal women taking 30 mcg ethinylestradiol and 3 mg drospirenone oral contraceptive.Contraception. 2008; 77: 344-349
- Functional and morphologic evaluation of the nasal mucosa before and after hormone therapy in postmenopausal women with nasal symptoms.Fertil Steril. 2003; 80: 669-671
- Sinonasal mucociliary clearance in health and disease.Ann Otol Rhinol Laryngol Suppl. 2006; 196: 20-26
- Does hormone replacement therapy in post-menopausal women have any effect upon nasal physiology?.J Laryngol Otol. 2008; 122: 707-710
- Evaluation of nasal mucociliary activity in patients with chronic renal failure.Eur Arch Otorhinolaryngol. 2015; ([Epub ahead of print])
- Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome: Rotterdam ESHRE/ASRM-sponsored 3rd PCOS Consensus Workshop Group.Fertil Steril. 2004; 81: 19-25
- Hirsutism—implications, etiology, and management.Am J Obstet Gynecol. 1981; 140: 815-830
- Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome.Diabetes. 1989; 38: 1165-1174
- The effect of the steroid sex hormones on the nasal airway during the normal menstrual cycle.Clin Otolaryngol Allied Sci. 2004; 29: 138-142
- Histological evaluation of rat larynx in experimental polycystic ovary syndrome model.Eur Arch Otorhinolaryngol. 2012; 269: 1945-1950
- Role of mechanical stress in regulating airway surface hydration and mucus clearance rates.Respir Physiol Neurobiol. 2008; 163: 189-201
- Aging, diabetes, and hypertension are associated with decreased nasal mucociliary clearance.Chest. 2013; 143: 1091-1097
- Deleterious effect of smoking and nasal septal deviation on mucociliary clearance and improvement after septoplasty.Am J Rhinol Allergy. 2009; 23: 2-7
- Tear function alterations in patients with polycystic ovary syndrome.Eur Rev Med Pharmacol Sci. 2015; 19: 3556-3562
- Metabolic syndrome and polycystic ovary syndrome: an intriguing overlapping.Gynecol Endocrinol. 2014; 30: 397-402
- Cytologic aspects of the nasal respiratory epithelium in postmenopausal women treated with hormone therapy.Fertil Steril. 2003; 79: 543-549
- Effect of gender on nasal mucociliary clearance.Int J Biomed Res. 2015; 6: 92-96
- The influence of age, sex and circadian rhythms on the nasal mucosal in the mucociliary clearance.An Otorrinolaringol Ibero Am. 1993; 20: 581-588
- Polycystic ovary syndrome.N Engl J Med. 2005; 352: 1223-1236
- Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis.Fertil Steril. 2011; 95: 1048-1058
- An update on the pathogenesis, inflammation, and metabolism in hirsutism and polycystic ovary syndrome.Gynecol Endocrinol. 2010; 26: 281-296
Article info
Publication history
Published online: October 26, 2016
Accepted:
October 18,
2016
Received in revised form:
September 8,
2016
Received:
March 17,
2016
Identification
Copyright
© 2016 Elsevier Ireland Ltd. All rights reserved.
