Abstract
Objective
To test the effect of aspirin and omega 3 on fetal weight as well as feto-maternal
blood flow in asymmetrical intrauterine growth restriction (IUGR).
Study design
This study is a clinically registered (NCT02696577), open, parallel, randomized controlled
trial, conducted at Assiut Woman’s Health Hospital, Egypt including 80 pregnant women
(28–30 weeks) with IUGR. They were randomized either to group I: aspirin or group
II: aspirin plus omega 3. The primary outcome was the fetal weight after 6 weeks of
treatment. Secondary outcomes included Doppler blood flow changes in both uterine
and umbilical arteries, birth weight, time and method of delivery and admission to
NICU. The outcome variables were analyzed using paired and unpaired t-test.
Results
The estimated fetal weight increased significant in group II more than group I (p = 0.00). The uterine and umbilical arteries blood flow increased significantly in group
II (p < 0.05). The birth weight in group II was higher than that observed in group I (p < 0.05).
Conclusion
The using of aspirin with omega 3 is more effective than using aspirin only in increasing
fetal weight and improving utero-placental blood flow in IUGR.
Keywords
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Article info
Publication history
Published online: January 03, 2017
Accepted:
January 2,
2017
Received in revised form:
December 28,
2016
Received:
August 16,
2016
Identification
Copyright
© 2017 Elsevier Ireland Ltd. All rights reserved.
