Abstract
Objective
The aim of this study was to compare the efficacy and tolerability of iron amino acid
chelate (IAAC) and ferrous fumarate (FF) in treatment of iron deficiency anemia (IDA)
with pregnancy.
Study design
A total of 150 pregnant women having iron deficiency anemia (IDA) were randomized
to receive either IAAC or FF for 12 weeks. Hemoglobin, red cell indices, serum iron,
and serum ferritin were measured at baseline and then 4, 8, and 12 weeks after treatment.
Adverse effects were questioned in both groups.
Results
The mean values of hemoglobin, red cell indices, serum iron, and serum ferritin were
not significantly different between both groups after 12 weeks of treatment. However,
the rise in hemoglobin level after 4, 8, and 12 weeks of treatment was significantly
faster in the IAAC group (p = <0.001). Constipation and abdominal colicky pain were significantly more common in
the FF group (p = 0.022 and 0.031 respectively).
Conclusion
IAAC and FF are comparable in curing IDA with pregnancy; however, IAAC has the advantage
of providing a faster rate of improvement of hemoglobin level and is better tolerated
by the patients.
Keywords
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Article info
Publication history
Published online: January 03, 2017
Accepted:
January 2,
2017
Received in revised form:
January 1,
2017
Received:
October 2,
2016
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
