In Hirschsprung’s disease, failure of the migration of neural crest cells during fetal development causes an aganglionic segment of the colon. The aganglionic segment fails to relax, whereas its proximal portion becomes dilated. Barium enema after birth effectively illustrates this morphology: the intestinal caliber abruptly changes, referred to as a colon “caliber change”.
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Published online: June 08, 2017
Accepted: June 4, 2017
Received in revised form: June 2, 2017
Received: January 5, 2017
© 2017 Elsevier B.V. All rights reserved.