In Hirschsprung’s disease, failure of the migration of neural crest cells during fetal
development causes an aganglionic segment of the colon. The aganglionic segment fails
to relax, whereas its proximal portion becomes dilated. Barium enema after birth effectively
illustrates this morphology: the intestinal caliber abruptly changes, referred to
as a colon “caliber change”.
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References
- Prenatal sonographic diagnosis of Hirschsprung's disease.J Ultrasound Med. 1986; 5: 37-39
- Fetal echogenic bowel at 17 weeks' gestational age as the early and only sign of a very long segment of Hirschsprung disease.J Ultrasound Med. 2008; 27: 1125-1126
- Retrospective analysis of prenatal ultrasound of children with Hirschsprung disease.Prenat Diagn. 2015; 35: 699-702
- Skip segment Hirschsprung's disease: a systematic.Pediatr Surg Int. 2010; 26: 1065-1069
Article info
Publication history
Published online: June 08, 2017
Accepted:
June 4,
2017
Received in revised form:
June 2,
2017
Received:
January 5,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.