Correspondence| Volume 215, P259-260, August 2017

Novel ultrasound finding of a fetus with Hirschsprung’s disease: A caliber change sign

      In Hirschsprung’s disease, failure of the migration of neural crest cells during fetal development causes an aganglionic segment of the colon. The aganglionic segment fails to relax, whereas its proximal portion becomes dilated. Barium enema after birth effectively illustrates this morphology: the intestinal caliber abruptly changes, referred to as a colon “caliber change”.
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