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Review article| Volume 224, P125-130, May 2018

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Mother-to-child transmission of hepatitis C virus

      Abstract

      Hepatitis C virus (HCV) infection is a worldwide health problem. Based on results of a serosurvey, global prevalence is estimated to be 2,5%, and women account for about 35.8% of the cases. For pregnant women the prevalence is lower and showed a range between 0.24% to 4.3%. Sinse mechanisms and timing of mother to child transmission are not fully understood, efforts are made to assess and understand its risk factors. The purpose of this review was to synthesize the evidence about the mother-to-child transmission of hepatitis C virus and review its risk factors.

      Keywords

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      References

        • Mohd Hanafiah K.
        • Groeger J.
        • Flaxman A.D.
        • Wiersma S.T.
        Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence.
        Hepatology. 2013; 57: 1333-1342
        • Petruzziello A.
        • Marigliano S.
        • Loquercio G.
        • Cozzolino A.
        • Cacciapuoti C.
        Global epidemiology of hepatitis C virus infection: an up-date of the distribution and circulation of hepatitis C virus genotypes.
        World J Gastroenterol [Internet]. 2016; (Available from:)
        • Beste L.A.
        • Bondurant H.C.
        • Ioannou G.N.
        Prevalence and management of chronic hepatitis C virus infection in women.
        Med Clin North Am [Internet]. 2015; 99 (Available from:): 575-586
        • Waruingi W.
        • Mhanna M.J.
        • Kumar D.
        • Abughali N.
        Hepatitis C Virus universal screening versus risk based selective screening during pregnancy.
        J Neonatal Perinatal Med [Internet]. 2015; 8 (Available from:): 371-378
        • Selvapatt N.
        • Ward T.
        • Bailey H.
        • Bennett H.
        • Thorne C.
        • See L.-M.
        • et al.
        Is antenatal screening for hepatitis C virus cost-effective? A decade’s experience at a London centre.
        J Hepatol [Internet]. 2015; 63 (Available from:): 797-804
        • Huang Q.−t.
        • Huang Q.
        • Zhong M.
        • Wei S.−s.
        • Luo W.
        • Li F.
        • et al.
        Chronic hepatitis C virus infection is associated with increased risk of preterm birth: a meta-analysis of observational studies.
        J Viral Hepat [Internet]. 2015; (Available from:)
        • Indolfi G.
        • Azzari C.
        • Resti M.
        Perinatal transmission of hepatitis C virus.
        J Pediatr [Internet] Elsevier Ltd. 2013; 163 (e1. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23919905): 1549-1552
        • Floreani A.
        Hepatitis C and pregnancy.
        World J Gastroenterol. 2013; 19: 6714-6720
        • Ward J.W.
        Hepatitis C virus: the 25-year journey from discovery to cure.
        Hepatology [Internet]. 2014; 60 (Available from:): 1479-1482
        • Yeung C.
        • Lee H.
        • Chan W.
        • Jiang C.
        • Chang S.
        • Chuang C.
        Vertical transmission of the hepatitis C virus: current knowledge and issues.
        Paediatr Child Health. 2008; 13: 529-541
        • Tosone G.
        • Maraolo A.E.
        • Mascolo S.
        • Palmiero G.
        • Tambaro O.
        • Orlando R.
        • et al.
        Vertical hepatitis C virus transmission: main questions and answers.
        World J Hepatol. 2014; 6: 538-548https://doi.org/10.4254/wjh.v6.i8.538
        • Le Campion A.
        • Larouche A.
        • Fauteux-Daniel S.
        • Soudeyns H.
        Pathogenesis of hepatitis C during pregnancy and childhood.
        Viruses. 2012; 4: 3531-3550
        • Sogni P.
        Pregnancy and viral hepatitis B and C.
        Presse Med [Internet]. 2015; 6 (Available from:)
        • Tovo P.-A.
        • Calitri C.
        • Scolfaro C.
        • Gabiano C.
        • Garazzino S.
        Vertically acquired hepatitis C virus infection: correlates of transmission and disease progression.
        World J Gastroenterol [Internet]. 2016; 22 (Available from:): 1382-1392
        • Pappalardo B.L.
        Influence of maternal human immunodeficiency virus (HIV) co-infection on vertical transmission of hepatitis C virus (HCV): a meta-analysis.
        Int J Epidemiol. 2003; 32: 727-734
        • Polis C.B.
        • Shah S.N.
        • Johnson K.E.
        • Gupta A.
        Impact of maternal HIV coinfection on the vertical transmission of hepatitis C virus: a meta-analysis.
        Clin Infect Dis. 2007; 44: 1123-1131
        • Snijdewind I.J.
        • Smit C.
        • Schutten M.
        • Nellen F.J.B.
        • Kroon F.P.
        • Reiss P.
        • et al.
        Low mother-to-child-transmission rate of Hepatitis C virus in cART treated HIV-1 infected mothers.
        J Clin Virol [Internet]. 2015; 68 (Available from: http://linkinghub.elsevier.com/retrieve/pii/S1386653215001146): 11-15
        • Tovo P.A.
        • Palomba E.
        • Ferraris G.
        • Principi N.
        • Ruga E.
        • Dallacasa P.
        • et al.
        Increased risk of maternal-infant hepatitis C virus transmission for women coinfected with human immunodeficiency virus type 1. Italian Study Group for HCV Infection in Children.
        Clin Infect Dis. 1997; 25: 1121-1124
        • Baroncelli S.
        • Pirillo M.F.
        • Amici R.
        • Tamburrini E.
        • Genovese O.
        • Ravizza M.
        • et al.
        HCV-HIV coinfected pregnant women: data from a multicentre study in Italy.
        Infection [Internet]. 2016; 44 (Available from:): 235-242
        • Indolfi G.
        • Bartolini E.
        • Serranti D.
        • Azzari C.
        • Resti M.
        Hepatitis C in children Co-infected with human immunodeficiency virus.
        J Pediatr Gastroenterol Nutr [Internet]. 2015; 61 (Available from:): 393-399
        • Delotte J.
        • Barjoan E.M.
        • Berrébi A.
        • Laffont C.
        • Benos P.
        • Pradier C.
        • et al.
        Obstetric management does not influence vertical transmission of HCV infection: results of the ALHICE group study.
        J Matern Neonatal Med [Internet]. 2014; 27 (Available from:): 664-670
        • Hayashida A.
        • Inaba N.
        • Oshima K.
        • Nishikawa M.
        • Shoda A.
        • Hayashida S.
        • et al.
        Re-evaluation of the true rate of hepatitis C virus mother-to-child transmission and its novel risk factors based on our two prospective studies.
        J Obstet Gynaecol Res. 2007; 33: 417-422
        • Indolfi G.
        • Azzari C.
        • Moriondo M.
        • Lippi F.
        • De Martino M.
        • Resti M.
        Alanine transaminase levels in the year before pregnancy predict the risk of hepatitis C virus vertical transmission.
        J Med Virol. 2006; 78: 911-914
        • Mor G.
        • Cardenas I.
        The immune system in pregnancy: a unique complexity.
        Am J Reprod Immunol. 2010; : 425-433
        • Della Bella S.
        • Riva A.
        • Tanzi E.
        • Nicola S.
        • Amendola A.
        • Vecchi L.
        • et al.
        Hepatitis C virus-specific reactivity of CD4+-lymphocytes in children born from HCV-infected women.
        J Hepatol. 2005; 43: 394-402
        • Babik J.M.
        • Cohan D.
        • Monto A.
        • Hartigan-O’Connor D.J.
        • McCune J.M.
        The human fetal immune response to hepatitis C virus exposure in utero.
        J Infect Dis [Internet]. 2011; 203 (Available from:): 196-206
        • Petit T.
        • Gluckman E.
        • Carosella E.
        • Brossard Y.
        • Brison O.
        • Socié G.
        A highly sensitive polymerase chain reaction method reveals the ubiquitous presence of maternal cells in human umbilical cord blood.
        Exp Hematol. 1995; 23: 1601-1605
        • Kisteneva L.B.
        • Cheshik S.G.
        • Samokhvalov E.I.
        • Moskovskaia I.A.
        • Malinovskaia V.V.
        • Suskova V.S.
        • et al.
        Perinatal transmission of hepatitis C virus.
        Vopr Virusol. 2016; 54: 12-15
        • Azzari C.
        • Moriondo M.
        • Indolfi G.
        • Betti L.
        • Gambineri E.
        • De Martino M.
        • et al.
        Higher risk of hepatitis C virus perinatal transmission from drug user mothers is mediated by peripheral blood mononuclear cell infection.
        J Med Virol. 2008; 80: 65-71
        • Nie Q.-H.
        • Gao L.-H.
        • Cheng Y.-Q.
        • Huang X.-F.
        • Zhang Y.-F.
        • Luo X.-D.
        • et al.
        Hepatitis C virus infection of human cytotrophoblasts cultured in vitro.
        J Med Virol [Internet]. 2012; 84 (Available from:): 1586-1592
        • Murakami J.
        • Nagata I.
        • Iitsuka T.
        • Okamoto M.
        • Kaji S.
        • Hoshika T.
        • et al.
        Risk factors for mother-to-child transmission of hepatitis C virus: maternal high viral load and fetal exposure in the birth canal.
        Hepatol Res. 2012; 42: 648-657
        • Mast E.E.
        • Hwang L.-Y.
        • Seto D.S.Y.
        • Nolte F.S.
        • Nainan O.V.
        • Wurtzel H.
        • et al.
        Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy.
        J Infect Dis. 2005; 192: 1880-1889
      1. A significant sex–but not elective cesarean section–effect on mother-to-child transmission of hepatitis C virus infection.
        J Infect Dis. 2005; 192: 1872-1879
        • Minola E.
        • Maccabruni A.
        • Pacati I.
        • Martinetti M.
        Amniocentesis as a possible risk factor for mother-to-infant transmission of hepatitis C virus.
        Hepatology (Baltim Md). 2001; : 1341-1342
        • Gagnon A.
        • Davies G.
        • Wilson R.D.
        • Genetics Committee
        • Wilson R.D.
        • Audibert F.
        • et al.
        Prenatal invasive procedures in women with hepatitis B, hepatitis C, and/or human immunodeficiency virus infections.
        J Obstet Gynaecol Can [Internet]. 2014; 36 (Available from:): 648-655
        • Prasad M.R.
        • Honegger J.R.
        Hepatitis C virus in pregnancy.
        Am J Perinatol. 2013; 30: 149-159
        • Review a.S.
        • Services U.S.P.
        • Force T.
        Annals of internal medicine review reducing risk for mother-to-infant transmission of hepatitis C virus.
        2014
        • European Paediatric C Hepatitis Virus Network
        Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus.
        BJOG Int J Obstet Gynaecol. 2001; 108: 371-377https://doi.org/10.1111/j.1471-0528.2001.00088.x
        • McMenamin M.B.
        • Jackson A.D.
        • Lambert J.
        • Hall W.
        • Butler K.
        • Coulter-Smith S.
        • et al.
        Obstetric management of hepatitis C-positive mothers: analysis of vertical transmission in 559 mother-infant pairs.
        Am J Obstet Gynecol. 2008; 199
        • Ghamar Chehreh M.E.
        • Tabatabaei S.V.
        • Khazanehdari S.
        • Alavian S.M.
        Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIV- mothers: a meta-analysis.
        Arch Gynecol Obstet. 2011; 283: 255-260
        • Cottrell E.B.
        • Chou R.
        • Wasson N.
        • Rahman B.
        • Guise J.M.
        Reducing risk for mother-to-infant transmission of hepatitis C virus: a systematic review for the U.S. preventive services task force.
        Ann Intern Med. 2013; : 109-113
        • Steininger C.
        • Kundi M.
        • Jatzko G.
        • Kiss H.
        • Lischka A.
        • Holzmann H.
        Increased risk of mother-to-infant transmission of hepatitis C virus by intrapartum infantile exposure to maternal blood.
        J Infect Dis [Internet]. 2003; 187 (Available from:): 345-551
        • Bhola K.
        • McGuire W.
        Does avoidance of breast feeding reduce mother-to-infant transmission of hepatitis C virus infection?.
        Arch Dis Child. 2007; 92: 365-366
        • Kumar R.M.
        • Shahul S.
        Role of breast-feeding in transmission of hepatitis C virus to infants of HCV-infected mothers.
        J Hepatol. 1998; 29: 191-197
        • Polywka S.
        • Schröter M.
        • Feucht H.H.
        • Zöllner B.
        • Laufs R.
        Low risk of vertical transmission of hepatitis C virus by breast milk.
        Clin Infect Dis. 1999; 29: 1327-1329
        • Zimmermann R.
        • Perucchini D.
        • Fauchère J.C.
        • Joller-Jemelka H.
        • Geyer M.
        • Huch R.
        • et al.
        Hepatitis C virus in breast milk.
        Lancet. 1995; : 928
        • Lam A.M.
        • Murakami E.
        • Espiritu C.
        • Micolochick Steuer H.M.
        • Niu C.
        • Keilman M.
        • et al.
        PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro- 2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
        Antimicrob Agents Chemother. 2010; 54: 3187-3196
        • Jacobson I.M.
        • Dore G.J.
        • Foster G.R.
        • Fried M.W.
        • Radu M.
        • Rafalsky V.V.
        • et al.
        Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): A phase 3, randomised, double-blind, placebo-controlled trial.
        Lancet [Internet] Elsevier Ltd. 2014; 384 (Available from:): 403-413
        • Nettles R.E.
        • Gao M.
        • Bifano M.
        • Chung E.
        • Persson A.
        • Marbury T.C.
        • et al.
        Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1.
        Hepatology [Internet]. 2011; 54 (Available from:): 1956-1965
        • Bacon B.R.
        • Gordon S.C.
        • Lawitz E.
        • Marcellin P.
        • Vierling J.M.
        • Zeuzem S.
        • et al.
        Boceprevir for previously treated chronic HCV genotype 1 infection.
        N Engl J Med. 2011; 364: 1207-1217https://doi.org/10.1056/NEJMoa1009482
        • Zeuzem S.
        • Andreone P.
        • Pol S.
        • Lawitz E.
        • Diago M.
        • Roberts S.
        • et al.
        Telaprevir for retreatment of HCV infection.
        N Engl J Med. 2011; 364: 2417-2428https://doi.org/10.1056/NEJMoa1013086