Abstract
Objectives
Matrix metalloproteinase-9, Nitric oxide and inflammation plays a role in the pathogenesis
of poly cystic ovary syndrome (PCOS). Even though these parameters are altered in
PCOS, the effect of clomiphene citrate on them has not been studied till date. The
present study was done to assess the effect of clomiphene citrate on matrix metalloproteinase-9,
nitric oxide and interleukin-10 levels in women with PCOS.
Study design
72 women diagnosed with PCOS were enrolled in the study. Matrix metalloproteinase-9,
nitric oxide and interleukin-10 levels were compared at baseline and after three weeks
following Clomiphene citrate treatment.
Results
Clomiphene citrate increases both nitric oxide (p = 0.03) and interleukin-10 (p < 0.001)
levels and reduces matrix metalloproteinase-9 levels (p < 0.001) in women with PCOS.
It also improves the ovulation rate (52.8%) and clinical pregnancy rate (19.4%) in
PCOS. Also there was a significant reduction in matrix metalloproteinase-9 levels
in both the ovulatory (p < 0.001) and conceived groups (p = 0.024) compared to non
ovulatory and non conceived group. There was no difference in nitric oxide and interleukin-10
levels in ovulatory and conceived groups compared to non ovulatory and non conceived
group.
Conclusion
We conclude that clomiphene citrate increases the levels of nitric oxide and interleukin-10
and decreases the matrix metalloproteinase - 9 levels and improves the ovulation rate
and clinical pregnancy rate in PCOS.
Abbreviations:
PCOS (Poly cystic ovary syndrome), CC (Clomiphene citrate), NO (Nitric oxide), MMP-9 (Matrix metalloproteinase-9), IL-10 (Interleukin-10)Keywords
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Article info
Publication history
Published online: June 08, 2018
Accepted:
June 4,
2018
Received in revised form:
April 16,
2018
Received:
January 18,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
