Abstract
This systematic review aimed to compare the clinical efficacy of tamoxifen with that
of clomiphene citrate (CC) in anovulatory patients. The PubMed, EMBASE, and CNKI databases
were searched up to October 2016 for literature comparing tamoxifen with CC in anovulatory
women. The pooled risk ratios (RR) or standardized mean differences (SMD) with 95%
confidence intervals (CIs) were subjected to statistical analysis. Twelve studies
involving 1302 patients with 2030 ovulation-induction cycles were summarized. There
were no statistically significant differences for the ovulation and pregnancy rates
in the tamoxifen comparing to the CC group in the pooled analysis. However, in the
subgroup of case-control studies, tamoxifen was identified to be associated with higher
ovulation (RR = 1.28, 95% CI: 1.07, 1.54, I2 = 0.0%) and pregnancy rates (RR = 1.82, 95% CI: 1.09, 3.06, I2 = 0.0%) than CC. However, no differences were detected in the subgroup of RCTs, even
after sensitivity analyses. In addition, no significant differences were found in
endometrial thickness and miscarriage rate. Our study showed that there might be some
distinctions in the efficacy of TMX and CC for ovulation and pregnancy rates. However,
the exact efficacy was needed to be confirmed further.
Keywords
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Article info
Publication history
Published online: June 12, 2018
Accepted:
June 11,
2018
Received in revised form:
April 5,
2018
Received:
January 3,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
