Abstract
Objective
To assess the impact of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic
pain.
Study design
Multicenter, open-label, non-comparative clinical trial in a representative sample
of women with endometriosis-associated pelvic pain.
Results
In total, 398 patients with a mean age of 34.6 ± 7.2 years were treated with a combination
of N-acetyl cysteine, alpha lipoic acid and bromelain for 6 months. At baseline, 92.7%
of the patients had pain intensity > 4 on the visual analogue scale (VAS); at 3 months
of treatment, this percentage decreased to 87.2% (p = 0.074) and at 6 months the percentage
was 82.7% (p < 0.05).
Conclusions
Women with endometriosis who wish to become pregnant and are treated with a preparation
containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement
in endometriosis-associated pelvic pain and required lower intake of rescue analgesics.
Keywords
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Article info
Publication history
Published online: July 06, 2018
Accepted:
July 2,
2018
Received in revised form:
May 11,
2018
Received:
March 16,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
