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Research Article| Volume 230, P32-35, November 2018

Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation

Published:September 11, 2018DOI:https://doi.org/10.1016/j.ejogrb.2018.09.016

      Abstract

      Objective

      Maternal thrombophilia is a risk factor for adverse pregnancy outcomes. The aim of this study was to elucidate the controversial role of fetal and paternal thrombophilia in the development of severe placenta-mediated pregnancy complications.

      Study Design

      The study group comprised 126 mothers, 72 fetuses and 58 fathers. 111 mothers, 50 fetuses and 91 fathers acted as controls. 106 couples were selected to study the thrombophilias of paternal inheritance, 58 from the study group and 48 from the control group. The prevalence of factor V Leiden mutation, prothrombin G20210 A mutation and homozygous 10-methylenetetrahydrofolate reductase C677 T mutations were compared between the study and control groups to study whether maternal, fetal or paternal thrombophilias increase the risk of severe preeclampsia, intrauterine growth restriction, placental abruption and stillbirth.

      Results

      The total prevalence of fetal thrombophilic mutations was 8.3% in the study group and 14.0% in the control group. Paternal prevalence of thrombophilic mutations was 6.8% and 4.3%, respectively. There were no statistical differences between fetal or paternal thrombophilic mutations between the study and control groups.

      Conclusion

      Fetal or paternal factor V Leiden mutation is not associated with severe placenta-mediated pregnancy complications.

      Keywords

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