Abstract
Objective
The aim of the study was to analyze interrelations between estradiol/testosterone
(E2/T) and estradiol/androstenedione (E2/A) indexes and nutritional status, insulin
resistance in PCOS.
Study design
A cross-sectional study involved 76 PCOS (41 obese) and 67 Non-PCOS (40 obese) women.
Anthropometric parameters and body composition were assessed. In fasting state of
serum glucose, androgens, estradiol, FSH, LH, SHBG and insulin were measured. E2/T
and E2/A indexes and the homeostasis model assessment of insulin resistance (HOMA-IR)
were calculated.
Results
The values of E2/T and E2/A indexes were significantly lower in the PCOS than Non-PCOS
subjects, but did not differ significantly between the obese and normal weight groups.
The lowest E2/T and E2/A values were observed in the normal weight PCOS group. Multivariable
regression analyses revealed that the presence of PCOS was the major factor affecting
both the log10 E2/T (β = −0.16) and log10 E2/A (β = −0.15) indexes. In addition, log10 E2/A index variability was explained by percentage of body fat (β = 0.57). HOMA-IR
was not among the explanatory factors in all above models.
Comment
The E2/A index is more affected by nutritional status than E2/T index. The lower value
of both indices in PCOS women with normal body mass suggest that aromatase activity
in PCOS are related to nutritional status.
Keywords
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Article info
Publication history
Published online: July 30, 2019
Accepted:
May 10,
2019
Received:
June 25,
2018
Identification
Copyright
© 2019 Published by Elsevier B.V.
