Highlights
- •We review the diagnostic approaches to lymph nodes involvement in cervical cancer.
- •We present the possible definitions for lymph nodes micrometastases (MMs) and isolated tumor cells (ITCs).
- •We describe the data regarding prognosis and treatment of patients diagnosed with cervical carcinoma with MMs or ITCs.
Abstract
Lymph node macroscopic involvement in cervical cancer is a well-known prognostic factor,
allows the gynecologic-oncologist to identify women at increased risk for recurrence.
Since the development of sentinel node biopsy, micrometastases (MMs) and Isolated
Tumor Cells (ICTs) have been increasingly identified in cervical cancer, however their
prognostic value and treatment are still controversial. We reviewed the literature
(MEDLINE and EMBASE database analysis) from inception up to January 2019, concerning
the incidence of lymph nodes MMs and ITCs in cervical cancer, their controversial
histologic and molecular biology definition, their anatomic distribution, the role
of frozen section and the prognostic value and treatment options for women diagnosed
with lymph nodes MMs/ITCs.
Keywords
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Article info
Publication history
Published online: August 19, 2019
Accepted:
August 18,
2019
Received in revised form:
August 13,
2019
Received:
March 26,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
