Abstract
Irisin is an important crosstalk myokine between adipose and muscle tissue. Disorders
in irisin secretion can lead to fetal growth abnormalities and even lead to metabolic
syndromes in adult life. This study aimed to evaluate the association between irisin
level in umbilical cord blood and maternal serum with neonatal birthweight. The Preferred
Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement and the
Meta-analysis of Observational Studies in Epidemiology (MOOSE) guideline were followed.
A comprehensive search of eight databases (PubMed, Embase, Web of Science, Cochrane
Central Register of Controlled Trials, CBM, CNKI, WANFANG and VIP) was performed from
inception to November 2019. Studies with original date reporting irisin levels in
newborns of small for gestational age (SGA) and newborns of large for gestational
age (LGA) were included. Additionally, studies reporting correlation coefficients
of irisin with birthweight were analyzed. Newcastle-Ottawa score system and Grading
of Recommendations, Assessment, Development and Evaluation (GRADE) approach were applied.
Seventeen studies with 1866 participants were included. Pooled analysis indicated
decreased cord irisin levels in SGA newborns (MD -10.57, 95 % CI -13.41 to -7.73)
and increased irisin levels in LGA newborns (MD 3.80, 95 % CI 1.91–5.70). Umbilical
cord irisin level was positively correlated with neonatal birthweight (r = 0.41 95
%CI 0.04 to 0.68). The pooled correlation coefficient of maternal serum irisin with
birthweight has no statistical significance. This meta-analysis suggested that the
umbilical cord irisin levels were impaired in fetal growth abnormalities. Umbilical
cord blood irisin level was positively correlated with birthweight.
Keywords
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Article info
Publication history
Published online: September 02, 2020
Accepted:
August 27,
2020
Received in revised form:
August 21,
2020
Received:
January 16,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
