Abstract
Objectives
To compare the effects of atosiban (oxytocin antagonist) on uterine peristalsis and
pregnancy outcomes in the frozen embryo transfer (FET) cycle.
Setting
Srinagarind Hospital, a university hospital, Khon Kaen, Thailand.
Design
A randomized, double-blinded, controlled trial.
Methods
Fifty infertile women were randomized into the atosiban (n = 25) and placebo group
(n = 25). Women in the study group received intravenous atosiban 6.75 mg, 30 min before
embryo transfer, and continued infusion at 18 mg/h for 1 h. The dose was reduced to
6 mg/h for another 2 h. Saline solution was applied in the placebo group. The uterine
peristalsis frequency was measured by transvaginal ultrasound 30 min before and 3 h
after the embryo transfer.
Results
The respective mean baseline uterine peristalsis frequency (time) in the atosiban
and placebo group was 10.3 ± 2.4 and 9.2 ± 3.4. The respective duration of uterine
peristalsis in the atosiban and placebo group after receiving the intervention was
reduced to 7.9 ± 2.1 and 6.9 ± 2.7. The implantation rate and clinical pregnancy rate
were not statistically significant different between atosiban group and placebo group
(37.5% versus 31.0%, RR 1.21, 95%CI: 0.60–2.44 and 44% versus 36%, RR 1.22, 95%CI:
0.62–2.42, respectively). Subgroup analysis indicated that the clinical pregnancy
rate in those >35 years of age was not significantly different between both groups
(31.6% and 18.8 %, RR 1.68, 95%CI: 0.50–5.68).
Conclusion
Adding atosiban in FET did not reduce uterine peristalsis but may benefit the advanced
age group.
Keywords
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Article info
Publication history
Published online: August 24, 2021
Accepted:
August 20,
2021
Received in revised form:
August 18,
2021
Received:
April 27,
2021
Identification
Copyright
© 2021 Published by Elsevier B.V.
