Abstract
Objective
The main objective of this study is to investigate the association of the NPHS1 gene polymorphisms (rs437168) and ACTN4 (rs3745895) in the pathogenesis of PE in women of African Ancestry.
Materials and methods
637 blood samples, normotensive pregnant (n = 280) and pre-eclampsia (n = 357) were
included. The PE group was sub-divided into early onset pre-eclampsia (n = 187) and
late onset pre-eclampsia (n = 170). rs74315346, rs869025495, rs121908415, rs3745895,
and rs437168 were genotyped from isolated DNA using real time PCR.
Results
The C allele of rs437168 (NPHS1) was significantly higher in PE compared to controls. [C vs T; p = 0.0323*] and [CC vs CT/TT; p = 0.0464*]. A comparison between the subtypes of PE and controls showed that the C allele was
significantly higher in EOPE compared to controls [p = 0.0027**], [CC vs CT/TT; p = 0.0111*], [CC/CT vs TT p = 0.0198*] and LOPE. [p = 0.0259*]. The other SNPs genotyped showed no signification associations with PE.
Conclusion
This study found that the C allele of rs437168 is significantly associated with the
pathogenesis of early onset PE and may be accountable for renal injury, which is a
risk factor for the development of EOPE in women of African Ancestry.
Keywords
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Article info
Publication history
Published online: September 13, 2021
Accepted:
September 8,
2021
Received in revised form:
August 18,
2021
Received:
May 24,
2021
Identification
Copyright
© 2021 Elsevier B.V. All rights reserved.
