Abstract
Objective
To characterize the association between antepartum marijuana exposure and maternal
and neonatal outcomes at our institution.
Study Design
Retrospective chart review identified an obstetric cohort of singleton gestations.
Women with self-reported marijuana use were compared with non-users. Demographic characteristics,
risk factors, and maternal-fetal outcomes were evaluated. Associations between outcomes
and marijuana use were assessed with regression analysis.
Results
Of 2792 deliveries, 5.4% reported marijuana use. Compared to non-users, marijuana
users entered prenatal care later, were younger, non-Hispanic, and used other illicit
substances. Marijuana users had a higher rate of cesarean delivery (p = 0.01). After
adjusting for confounders, marijuana use remained associated with 4.1-fold risk of
delivering a small for gestational age (SGA) infant and 2.89-fold risk of neonatal
oxygen use.
Conclusion
At a safety net hospital, antepartum marijuana use is significantly associated with
cesarean delivery, SGA and supplemental oxygen use at birth. Healthcare disparities
associated with marijuana use make this a population of critical interest.
Keywords
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References
Practice CoO. Committee Opinion No. 722: Marijuana Use During Pregnancy and Lactation. Obstet Gynecol. 2017;130(4):e205-e9.
- Trends in perception of risk of regular marijuana use among US pregnant and nonpregnant reproductive-aged women.Am J Obstet Gynecol. 2017; 217: 705-707
- Maternal marijuana use and neonatal morbidity.Am J Obstet Gynecol. 2015; 213 (422.e1 4)
- Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009–2016.Drug Alcohol Depend. 2019; 196: 66-70
- Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy.JAMA Netw Open. 2019; 2: e196471https://doi.org/10.1001/jamanetworkopen.2019.6471
- Recommendations From Cannabis Dispensaries About First-Trimester Cannabis Use.Obstet Gynecol. 2018; 131: 1031-1038
- Pregnant Women's Current and Intended Cannabis Use in Relation to Their Views Toward Legalization and Knowledge of Potential Harm.J Addict Med. 2017; 11: 211-216
- Survey of medicinal cannabis use among childbearing women: patterns of its use in pregnancy and retroactive self-assessment of its efficacy against 'morning sickness'.Complement Ther Clin Pract. 2006; 12: 27-33
- Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents.Psychopharmacology. 2011; 214: 5-15
- Smoking and marijuana use in pregnancy.Clin Obstet Gynecol. 2013; 56: 107-113
- Pregnancy, breast-feeding, and marijuana: a review article.Obstet Gynecol Surv. 2013; 68: 710-718
- Marijuana: prenatal and postnatal exposure in the human.NIDA Res Monogr. 1985; 59: 48-60
- Plasma concentrations of delta-9-tetrahydrocannabinol in dams and fetuses following acute or multiple prenatal dosing in rats.Life Sci. 1989; 44: 697-701
- Prevalence of illicit drug use in pregnant women in a Wisconsin private practice setting.Am J Obstet Gynecol. 2014; 211 (255.e1 4)
- Trends in Marijuana Use Among Pregnant and Nonpregnant Reproductive-Aged Women, 2002–2014.JAMA. 2017; 317: 207-209
- Marijuana Use in Pregnancy and While Breastfeeding.Obstet Gynecol. 2018; 132: 1198-1210
- Childhood ASTALSoPa. Maternal use of cannabis and pregnancy outcome.BJOG. 2002; 109: 21-27
- Association between marijuana use and adverse obstetrical and neonatal outcomes.J Perinatol. 2015; 35: 991-995
- Birth outcomes associated with cannabis use before and during pregnancy.Pediatr Res. 2012; 71: 215-219
- Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis.BMJ Open. 2016; 6: e009986https://doi.org/10.1136/bmjopen-2015-009986
- Maternal Marijuana Use and Adverse Neonatal Outcomes: A Systematic Review and Meta-analysis.Obstet Gynecol. 2016; 128: 713-723
- Effect of marijuana use in pregnancy on fetal growth.Am J Epidemiol. 1986; 124: 986-993
- Identifying prenatal cannabis exposure and effects of concurrent tobacco exposure on neonatal growth.Clin Chem. 2010; 56: 1442-1450
- Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study.J Am Acad Child Adolesc Psychiatry. 2009; 48: 1173-1181
- Marijuana use in young mothers and adverse pregnancy outcomes: a retrospective cohort study.BJOG. 2019; 126: 1491-1497
- Outcomes in young adulthood for very-low-birth-weight infants.N Engl J Med. 2002; 346: 149-157
- Behavioral outcomes and evidence of psychopathology among very low birth weight infants at age 20 years.Pediatrics. 2004; 114: 932-940
- Racial Disparities in Adverse Pregnancy Outcomes and Psychosocial Stress.Obstet Gynecol. 2018; 131: 328-335
- Birth outcome racial disparities: A result of intersecting social and environmental factors.Semin Perinatol. 2017; 41: 360-366
- Preconception and prenatal cannabis use and the risk of behavioural and emotional problems in the offspring; a multi-informant prospective longitudinal study.Int J Epidemiol. 2019; 48: 287-296
- Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana.Neurotoxicol Teratol. 2003; 25: 427-436
Article info
Publication history
Published online: September 15, 2021
Accepted:
September 13,
2021
Received in revised form:
August 31,
2021
Received:
May 11,
2021
Footnotes
☆Previously accepted at: ACOG Annual Clinical and Scientific Meeting. April 2020. Seattle, Washington.
Identification
Copyright
© 2021 Published by Elsevier B.V.
