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Intra-ovarian infusion of autologous platelet-rich plasma in women with poor ovarian reserve: A before and after study

  • Robabe Hosseinisadat
    Affiliations
    Department of Obstetrics and Gynecology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
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  • Alireza Farsi Nejad
    Correspondence
    Corresponding author at: Kerman University of Medical Sciences, Kerman 7619813159, Iran.
    Affiliations
    Department of Hematology and Laboratory Sciences, School of Paramedical Sciences, Kerman University of Medical Sciences and Health Services, Kerman, Iran

    Pathology and Stem Cell Research Center, Kerman University of Medical Sciences and Health Services, Kerman, Iran
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  • Frough Mohammadi
    Affiliations
    Department of Obstetrics and Gynecology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
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Published:November 04, 2022DOI:https://doi.org/10.1016/j.ejogrb.2022.11.001

      Abstract

      Objective

      Female ovarian reserve progressively declines with increasing age. Intraovarian injection of platelet-rich plasma (PRP) seems to be an alternative treatment to increase fertility in women. Therefore, this study aimed to evaluate the effect of intra-ovarian infusion of PRP in treating women with poor ovarian reserve.

      Materials and Methods

      In this before-and-after study, 22 infertile women with a poor ovarian reserve who underwent in vitro fertilization with the GnRH antagonist protocol were enrolled. After the oocyte retrieval undergoing vaginal ultrasound guide, PRP was injected into the ovary with a puncture needle under general anesthesia. Finally, the levels of anti-Müllerian hormone (AMH) and antral follicle counts (AFCs) were compared in all participants before and three months after the PRP injection.

      Results

      Our findings showed that AMH significantly increased after the intra-ovarian infusion of PRP (P < 0.001) in these women, while no significant changes were observed in AFC (P = 0.140) at the end of the study. In addition, logistic regression indicated that body mass index (BMI) and maternal age had no significant effect on ovarian response to PRP injection. However, the duration of infertility > 5 years was associated with a 20-fold increase in the probability of AFC < 7 in women with poor ovarian reserve.

      Conclusions

      PRP can increase the chance of fertility in women with poor ovarian reserve by significantly increasing AMH levels.

      Keywords

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