Abstract
Objective
Female ovarian reserve progressively declines with increasing age. Intraovarian injection
of platelet-rich plasma (PRP) seems to be an alternative treatment to increase fertility
in women. Therefore, this study aimed to evaluate the effect of intra-ovarian infusion
of PRP in treating women with poor ovarian reserve.
Materials and Methods
In this before-and-after study, 22 infertile women with a poor ovarian reserve who
underwent in vitro fertilization with the GnRH antagonist protocol were enrolled.
After the oocyte retrieval undergoing vaginal ultrasound guide, PRP was injected into
the ovary with a puncture needle under general anesthesia. Finally, the levels of
anti-Müllerian hormone (AMH) and antral follicle counts (AFCs) were compared in all
participants before and three months after the PRP injection.
Results
Our findings showed that AMH significantly increased after the intra-ovarian infusion
of PRP (P < 0.001) in these women, while no significant changes were observed in AFC
(P = 0.140) at the end of the study. In addition, logistic regression indicated that
body mass index (BMI) and maternal age had no significant effect on ovarian response
to PRP injection. However, the duration of infertility > 5 years was associated with
a 20-fold increase in the probability of AFC < 7 in women with poor ovarian reserve.
Conclusions
PRP can increase the chance of fertility in women with poor ovarian reserve by significantly
increasing AMH levels.
Keywords
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Article info
Publication history
Published online: November 04, 2022
Accepted:
November 1,
2022
Received in revised form:
October 27,
2022
Received:
June 22,
2022
Identification
Copyright
© 2022 Published by Elsevier B.V.
