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Research Article| Volume 280, P22-27, January 2023

Comparing pregnancy rates following ovarian stimulation with follitropin-Δ to follitropin -α in routine IVF: A retrospective analysis

  • Peter Kovacs
    Correspondence
    Corresponding author.
    Affiliations
    Dunamenti REK, IVF Center, Budapest, Hungary

    Dunamenti REK, IVF Center, Istenhegyi ut 54/a, Budapest, Hungary
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  • Jayapriya Jayakumaran
    Affiliations
    University of Central Florida College of Medicine, Department of Obstetrics and Gynecology, Orlando, FL 32827, United States
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  • Yao Lu
    Affiliations
    Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China

    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, PR China
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  • Steven R Lindheim
    Affiliations
    University of Central Florida College of Medicine, Department of Obstetrics and Gynecology, Orlando, FL 32827, United States

    Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, PR China

    Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, PR China

    Wright State University Boonshoft School of Medicine, Dayton, OH, 45409 USA
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Published:November 08, 2022DOI:https://doi.org/10.1016/j.ejogrb.2022.11.006
Comparing pregnancy rates following ovarian stimulation with follitropin-Δ to follitropin -α in routine IVF: A retrospective analysis
Previous ArticleComparison of relaxant effects of nifedipine and NS11021 on isolated umbilical arteries of healthy and preeclamptic pregnant women
Next ArticleAssisted human reproduction legislation: Acknowledging the voice of health care professionals

      Highlights

      • •
        Follitropin—Δ is associated with increased FSH exposure due to unique glycosylation.
      • •
        RCTs reported reduced gonadotropin need and more optimal response with follitropin- Δ.
      • •
        RCTs included selected, better prognosis patients.
      • •
        Retrospective analyses of REI practice’s experience with follitropin- Δ.
      • •
        Less than “ideal” patients suggest similar findings to RCTs.

      Abstract

      Study objectives

      Follitropin-Δ, a new recombinant follicle stimulation hormone, uses a fixed daily dose producing a predictable ovarian response while using less gonadotropins compared to follitropin-α. We report clinical outcomes comparing each in the routine IVF setting and further compare qualified to disqualified subjects based on previous randomized controlled trial (RCT) inclusion criteria.

      Study design

      Retrospective analysis of all cycles performed by a single provider between January 2020 to January 2021. All IVF cycles without patient inclusion–exclusion criteria were considered for the analysis. Clinical outcomes in two groups (follitropin-Δ vs follitropin-α ± 75 IU human menopausal gonadotropin (hMG) in expected poor responders) were compared. In addition, comparisons were made between qualified versus disqualified subgroups.

      Results

      No differences in baseline demographics, number of MII oocytes, fertilization/MII oocyte, percent of good quality embryos were noted. Compared to those using follitropin-α, follitropin-Δ resulted in lower daily (170 vs 211 IU/d, p = 0.002) and total Gn used (1739 vs 2194 IU, p = 0.003). Optimal range response (8–14 oocytes) (22/44 [50 %] vs 78/203 [38.6 %]; p = 0.10) and fresh (fCP) and cumulative clinical pregnancy (cCP) rates per transfer (29.5 % vs 24.1 % and 35 % vs 25.1 %, p = 0.08) were similar between groups. Based on previous RCTs, those who would have qualified compared to those who would have disqualified, patients using follitropin-Δ were just as likely to have an optimal oocyte response (qualified: 48 % vs disqualified: 57.1 %) and resulted in similar cCP (41.4 % vs 25 %, p-0.23).

      Conclusions

      While follitropin-Δ requires less daily and total dosing compared to follitropin-α, optimal range of retrieved oocytes and clinical outcomes appear to be comparable. Using RCT inclusion criteria, similar findings were noted in those who would have qualified compared to disqualified patients.

      Keywords

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      Article info

      Publication history

      Published online: November 08, 2022
      Accepted: November 6, 2022
      Received in revised form: September 5, 2022
      Received: March 29, 2022

      Identification

      DOI: https://doi.org/10.1016/j.ejogrb.2022.11.006

      Copyright

      © 2022 Elsevier B.V. All rights reserved.

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