Abstract
The aim of this work was to evaluate whether serum cytokines levels are associated
with ovarian response in IVF. 149 patients were included in a retrospective study.
Cytokines IL-2, IL-4, IL- 6, IL-8, IL-10, VEGF, IFNγ, TNFα, IL-1α, IL-1β, MCP-1 and
EGF were measured by sandwich immunoassay previously to ovarian stimulation. Performing
hierarchical cluster analysis, we observed that the antral follicle count, the total
oocytes recovered and the MII recovered are grouped in the same cluster as the cytokines
IL-2–4-6–10-1α-1β, IFNγ y TNFα. Then, we found that the ratio between IL and 6 and
IL-10 was higher in low responder women (2.15 versus 1.55; p = 0.035). If we establish
0.9 as a cut-off for the IL-6/IL-10, we observed that above this value the risk of
having a low response to ovarian stimulation was more than 3 times greater than below
this value (22.9 % versus 6.0 %; p = 0.007). Also, the ratio IL-1β/IL-4 was higher
in patients with normal or suboptimal response (0.62 versus 0.34; p = 0.034) and any
patient with low response had a value greater than 0.7 (p = 0.003). As a conclusion,
the IL-6/IL-10 and IL-1β/IL-4 ratios showed differences between normoresponder women
and patients with low ovarian response.
Keywords
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Article info
Publication history
Published online: November 17, 2022
Accepted:
November 11,
2022
Received in revised form:
November 4,
2022
Received:
May 16,
2022
Identification
Copyright
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