Abstract
Objectives
Potassium (K+) channel openers and calcium (Ca2+) channel blockers are currently used to treat acute severe hypertension in pregnancy.
We aimed to investigate the vasorelaxant effect of NS11021, a potent and specific
big-conductance Ca2+-activated K+ (BKCa) channel activator, and to compare it with the vasorelaxant effect of nifedipine
on human umbilical arteries (HUAs) isolated from healthy and preeclamptic pregnants.
Study design
A total of 29 HUAs were isolated immediately after delivery from 14 healthy and 15
preeclamptic pregnant with severe features. The concentration-dependent relaxation
responses were obtained to nifedipine and NS11021 on HUAs precontracted with endothelin-1
(ET-1) (10-8 M) in an isolated tissue bath.
Results
Both nifedipine and NS11021 caused concentration-dependent relaxation responses in
HUAs from healthy and preeclamptic pregnants. While the maximum responses (Emax) and
pD2 values of nifedipine did not change significantly in both groups, the Emax and pD2 values of NS11021 were significantly decreased in the preeclampsia group (Emax ± SEM;
%75.57 ± 4.53 and %43.75 ± 14.00 and pD2 ± SEM; 6.92 ± 0.26 and 5.24 ± 0.53 respectively, p < 0.05). In addition, the pD2 value of NS11021 was not significantly different from that of nifedipine in the control
group, but decreased significantly in the preeclampsia group (pD2 ± SEM 7.1 ± 0.41 and 5.2 ± 0.53, p < 0.05, respectively).
Conclusions
Efficacy and potency of NS11021 decreased in HUAs from preeclamptic pregnants. Also,
NS11021 is less potent than nifedipine in the preeclampsia group. BKCa channels may
have a role in the pathogenesis of preeclampsia, however, further experimental studies
are needed to elucidate that.
Keywords
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Article info
Publication history
Published online: December 08, 2022
Accepted:
December 5,
2022
Received in revised form:
November 8,
2022
Received:
June 9,
2022
Identification
Copyright
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