Abstract
Objectives
To evaluate the serum level of prolidase, which is a marker of fibrogenic activity, in women with idiopathic primary ovarian insufficiency
(POI).
Study Design
This is a prospective case-control study. Serum prolidase level was compared between
the study group including 68 women with POI and control group including 65 normally
menstruating women. Serum proline and hydroxyproline levels were also compared. Correlation
analyses were performed between the prolidase level and POI related parameters including
estradiol (E), follicle stimulating hormone (FSH), anti-mullerian hormone (AMH) levels,
and presence of POI family history.
Results
Serum prolidase and proline level were significantly increased in women with the diagnosis
of POI compared to the control group (1082.57 (147.53) vs 981.13 (223.26) U/L, 233.30
(83.16) vs 218.94 (82.59) µmol/L, respectively). Prolidase level found to have significant
correlations with AMH, E, FSH levels, and presence of POI family history (r = −0.49,
p = 0.001; r = −0.39, p = 0.001; r = 0.42, p = 0.001; r = 0.22, p = 0.01; respectively).
In receiver operating characteristics analysis, prolidase was shown to be a discriminative
factor for POI at 1031.14 U/L cut-off value with 75 % sensitivity and 65 % specificity.
The area under curve was 0.71 [(95 % CI: 0.62–0.79), p = 0.001].
Conclusion
The current study revealed increased prolidase level in women with POI. Serum prolidase level was also negatively correlated with the serum AMH level.
Considering the present findings, prolidase may be a candidate molecule in assessment of POI cases.
Keywords
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Article info
Publication history
Published online: December 10, 2022
Accepted:
December 6,
2022
Received in revised form:
October 30,
2022
Received:
July 27,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
