Abstract
Objective
To evaluate the influence of the day 3 embryo cell number on the neonatal outcomes
of day 5 single blastocyst transfer in frozen embryo transfer (FET) cycles.
Methods
This retrospective study analysed a total of 2315 delivery cycles of day 5 single
blastocyst transfer in FET cycles, including 489, 761 and 1103 live-born infants segregated
according to a day 3 embryo cell number of <8, 8 and >8 cells, respectively. The neonatal
outcomes of the three groups were compared.
Results
The day 3 embryo cell number did not significantly affect the incidence of monozygotic
twins. The sex ratio increased as the day 3 embryo cell number increased, but the
difference was not statistically significant. There were no significant differences
in the rates of preterm birth or low birth weight among the three groups. The rates
of stillbirths and neonatal deaths were also not significantly different among the
three groups. Moreover, the day 3 embryo cell number did not increase the risk of
birth defects in newborns.
Conclusions
The day 3 embryo cell number did not significantly affect neonatal outcomes.
Keywords
Abbreviations:
FET (frozen embryo transfer), IVF (in vitro fertilization), ICSI (intracytoplasmic sperm injection), LBW (low birth weight), ART (assisted reproductive technology), rFSH (recombinant follicle stimulating hormone), hCG (human chorionic gonadotropin), BMI (body mass index), MZT (monozygotic twins), PGT (preimplantation genetic testing), aOR (adjusted odds ratio), CI (confidence interval)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 10, 2023
Accepted:
February 8,
2023
Received in revised form:
February 4,
2023
Received:
August 13,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
