Polyhydramnios occurs in 1–2 % pregnancies [
]. In about 5 % of cases the polyhydramnios is severe. There are generally two major etiologies: reduced fetal swallowing and increased fetal urination. Severe and persistent polyhydramnios is an adverse sign for a pregnancy. This is largely due to two factors: the likely presence of an underlying abnormality associated with polyhydramnios and the increased incidence of preterm labor caused by increased uterine pressure. We herein report such a case, confirmed to have Bartter syndrome (BS) in utero by using rapid exome sequencing (ES).
- Hill L.M.
- Breckle R.
- Thomas M.L.
- Fries J.K.
Polyhydramnios: ultrasonically detected prevalence and neonatal outcome.
Obstet Gynecol. 1987; 69: 21-25
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to European Journal of Obstetrics and Gynecology and Reproductive Biology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Polyhydramnios: ultrasonically detected prevalence and neonatal outcome.Obstet Gynecol. 1987; 69: 21-25
- Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2.Nat Genet. 1996; 13: 183-188
- Idiopathic polyhydramnios and postnatal abnormalities.Fetal Diagn Ther. 2012; 32: 251-255
- Bartter syndrome: an overview.QJM. 2000; 93: 207-215
- Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome.Nephrol Dial Transplant. 2009; 24: 1455-1464
Published online: February 14, 2023
Accepted: February 12, 2023
Received: February 9, 2023
© 2023 Elsevier B.V. All rights reserved.