Abstract
Objective: To evaluate the fetal renal maturation by assessment of amniotic fluid microproteins
and to show these proteins originate from fetal urine. Study design: Amniotic fluid proteins (total protein, albumin, high molecular weight protein-HMWP,
low molecular weight protein-LMWP, α1-microglobulin and β2-microglobulin) were determined in 39 pregnant women at delivery and by amniocentesis
in 30 pregnant women. These values were compared with first urine values of neonates
with the same gestational age. Results: Albumin was the largest protein component in the amniotic fluid. LMWP showed an increase
in the amniotic fluid until the end of the second trimester; and as pregnancy advanced
a progressive decrease occurred in parallel to fetal renal maturation. After 26 weeks’
gestation, a strong correlation was identified between LMWP levels and α1-microglobulin, and between LMWP and β2-microglobulin. No significant difference was detected between LMWP levels in the
first urine of the neonates and in amniotic fluids. Conclusion: Microproteins in the fetal urine are of fetal origin. Fetal renal maturation can
be evaluated by measuring microproteins in the amniotic fluid. Fetal renal maturation
is best reflected by α1-microglobulin.
Keywords
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Article info
Publication history
Accepted:
August 2,
1999
Received in revised form:
June 21,
1999
Received:
September 4,
1998
Identification
Copyright
© 2000 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
